Adam M Gilbert

US Patent:

6465482, Oct 15, 2002

Filed:

Oct 3, 2001

Appl. No.:

09/969910

Inventors:

Richard E. Mewshaw - King of Prussia PA
Ping Zhou - Plainsboro NJ
Dahui Zhou - East Brunswick NJ
Kristin L. Meagher - Hightstown NJ
Magda Asselin - Mahwah NJ
Deborah A. Evrard - Hamilton Square NJ
Adam M. Gilbert - Congers NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31454

US Classification:

514300, 514307, 514314, 514318, 514323, 546113, 546148, 546176, 546194, 546201

Abstract:

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R , R and R are each, independently, hydrogen, halogen, CF , alkyl, alkoxy, MeSO , or together can form a 5-7 membered carbocyclic or heterocyclic ring; R is hydrogen, halogen, or alkyl; R is hydrogen, alkyl, alkylaryl, or aryl; R is hydrogen, halogen, CF , CN, carbamide, or alkoxy; X , X and X are each carbon or one of X , X or X may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.

US Patent:

6780860, Aug 24, 2004

Filed:

Apr 25, 2002

Appl. No.:

10/131917

Inventors:

Gary P. Stack - Ambler PA
Adam M. Gilbert - Congers NY
Megan Tran - Hoboken NJ

Assignee:

Wyeth - Madison NJ

International Classification:

C07D40714

US Classification:

514241, 514256, 514304, 544180, 544333, 546126

Abstract:

Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimers disease or other neurodegenerative diseases, or schizophrenia and are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such eating disorders, disorders of thermoregulation, and sleep and sexual dysfunction.

US Patent:

6861427, Mar 1, 2005

Filed:

Apr 24, 2002

Appl. No.:

10/131355

Inventors:

Gary P. Stack - Ambler PA, US
Adam M. Gilbert - Congers NY, US
Megan Tran - Hoboken NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K031/53
A61K031/519
A61K031/498
C07D487/02

US Classification:

514243, 514249, 514267, 544184, 544212, 544251, 544345

Abstract:

Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia, and are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such eating disorders, disorders of thermoregulation, and sleep and sexual dysfunction.

US Patent:

7381723, Jun 3, 2008

Filed:

Jun 28, 2004

Appl. No.:

10/878715

Inventors:

Gary P. Stack - Ambler PA, US
Megan Tran - Hoboken NJ, US
Adam M. Gilbert - Congers NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A01N 43/66
A01N 43/54
A01N 43/42
A61K 31/53
A61K 31/44
C07D 239/42
C07D 401/04
C07D 403/00
C07D 401/00
C07D 405/00
C07D 411/00
C07D 413/00
C07D 417/00
C07D 419/00
C07D 421/00
C07C 409/00

US Classification:

514241, 514256, 514304, 544209, 544333, 546126

Abstract:

Compounds of the formula.

US Patent:

20060264437, Nov 23, 2006

Filed:

Dec 16, 2004

Appl. No.:

11/013577

Inventors:

Gary Stack - Ambler PA, US
Adam Gilbert - Congers NY, US
Megan Tran - Hoboken NJ, US

International Classification:

A61K 31/53
A61K 31/519
A61K 31/498
C07D 491/02

US Classification:

514241000, 514250000, 514267000, 544209000, 544250000, 544345000

Abstract:

Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia, and are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such eating disorders, disorders of thermoregulation, and sleep and sexual dysfunction.

US Patent:

20090048282, Feb 19, 2009

Filed:

Aug 14, 2008

Appl. No.:

12/191388

Inventors:

Diane Barbara Hauze - Wayne PA, US
Matthew Gregory Bursavich - Salt Lake City UT, US
Luciana de Araujo Felix - Broomall PA, US
Adam Matthew Gilbert - Congers NY, US
Jeffrey Claude Pelletier - Lafayette Hill PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/506
A61P 35/00
C07D 417/02

US Classification:

514275, 544330, 544331

Abstract:

The present invention relates to pyrimidine sulfonamide analogs, methods of making pyrimidine sulfonamide analogs, compositions comprising a pyrimidine sulfonamide analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a pyrimidine sulfonamide analog.

US Patent:

63131269, Nov 6, 2001

Filed:

Dec 30, 1999

Appl. No.:

9/476254

Inventors:

Richard E. Mewshaw - King of Prussia PA
Ping Zhou - Plainsboro NJ
Dahui Zhou - East Brunswick NJ
Kristin L. Meagher - Hightstown NJ
Magda Asselin - Mahwah NJ
Deborah A. Evrard - Hamilton Square NJ
Adam M. Gilbert - Congers NY

Assignee:

American Home Products Corp - Madison NJ

International Classification:

A61K 31496
A61K 31498
C07D40114
C07D40314
C07D40514

US Classification:

514249

Abstract:

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise ##STR1## Wherein: R. sub. 1, R. sub. 2 and R. sub. 3 are each, independently, hydrogen, halogen, CF. sub. 3, alkyl, alkoxy, MeSO. sub. 2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R. sub. 4 is hydrogen, halogen, or alkyl; R. sub. 5 is hydrogen, alkyl, alkylaryl, or aryl; R. sub. 6 is hydrogen, halogen, CF. sub. 3, CN, carbamide, or alkoxy; X. sub. 1, X. sub. 2 and X. sub. 3 are each carbon or one of X. sub. 1, X. sub. 2 or X. sub. 3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.