Alan H Jacobson

Address:

70 Beaver Rd, Weston, MA 02493

Phone:

(781)2370553

VIN:

JNKAY01F68M656223

Make:

INFINITI

Model:

M35

Year:

2008

US Patent:

20110034521, Feb 10, 2011

Filed:

Sep 19, 2008

Appl. No.:

12/677055

Inventors:

Alan Jacobson - Cambridge MA, US
Scott Moe - Sudbury MA, US

International Classification:

A61K 31/167
C07C 233/01
C07D 231/38
C07D 409/04
C07D 213/72
A61K 31/415
A61K 31/44
C12N 9/50
A61P 35/00

US Classification:

514352, 564192, 5483725, 5483657, 546312, 514625, 514407, 435219

Abstract:

The present invention provides compounds and methods for treating zinc matrix metalloprotease dependent diseases. In certain embodiments, the compounds of the present invention have the following formulas:

US Patent:

56772823, Oct 14, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/473143

Inventors:

Jozef Oleksyszyn - Arlington MA
Alan R. Jacobson - Somerville MA

Assignee:

Proscript, Inc. - Cambridge MA

International Classification:

C07K 508
C07K 506
A61K 3141

US Classification:

514118

Abstract:

Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, are also disclosed.

US Patent:

56463162, Jul 8, 1997

Filed:

Apr 25, 1995

Appl. No.:

8/430129

Inventors:

Alan R. Jacobson - Somerville MA
Douglas G. Gabler - Cambridge MA
Jozef Oleksyszyn - Arlington MA

Assignee:

OsteoArthritis Sciences, Inc. - Cambridge MA

International Classification:

C07J 900
C07J 4100

US Classification:

552554

Abstract:

The present invention relates to a bile acid derivative, which comprises a bile acid derivatized at the carboxyl group with a hydroxamic acid or hydroxamate ester. The carboxyl group in the bile acid compound can also be derivatized with an amino acid or oligopeptide, whose C-terminus is derivatized with a hydroxamic acid or a hydroxamate ester. The present invention also relates to a method of use of a bile acid or a bile acid derivative to inhibit a metalloproteinase enzyme, comprising contacting a metalloproteinase with an effective amount of a bile acid or bile acid derivative. In another embodiment, the present invention further relates to a method of use of a bile acid or bile acid derivative to therapeutically treat a disease, which is ameliorated by inhibiting a metalloproteinase enzyme. In this method, a therapeutically effective amount of a bile acid, a bile acid derivative or physiologically acceptable salts thereof, is administered to a human or other mammal.