Alexandria L Forbes

US Patent:

20230021959, Jan 26, 2023

Filed:

Dec 7, 2020

Appl. No.:

17/782357

Inventors:

- New York NY, US
- Ithaca NY, US
- London, GB
Samuel D. WAKSAL - New York NY, US
Alexandria FORBES - New York NY, US
Yasir H. QURESHI - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY
Cornell University - Ithaca NY
Meiragtx UK II Limited - London

International Classification:

C07K 14/47

Abstract:

The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative disorders. Additionally, the disclosure relates to adenoviral based therapy for treating Alzheimer's disease (AD), and other neurodegenerative conditions such as Parkinson's Disease (PD), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), Down's syndrome, and hereditary spastic paraplegia, as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), Lewy Body Disease (LBD), amyotrophic lateral sclerosis (ALS), frontal-temporal degeneration (FTD), ALS-FTD, and chronic traumatic encephalopathy (CTE).

US Patent:

20200239940, Jul 30, 2020

Filed:

Aug 3, 2017

Appl. No.:

16/322865

Inventors:

- London, GB
Alexandria Forbes - New York NY, US
Lei Feng - Bronx NY, US

Assignee:

MeiraGTx UK II Limited - London

International Classification:

C12Q 1/6811
C12N 15/10
C12N 15/115

Abstract:

The invention provides eukaryotic cell-based screening methods to identify an aptamer that specifically binds a ligand, or a ligand that specifically binds an aptamer, using a polynucleotide cassette for the regulation of the expression of a reporter gene where the polynucleotide cassette contains a riboswitch in the context of a 5′ intron-alternative exon-3′ intron. The riboswitch comprises an effector region and an aptamer such that when the aptamer binds a ligand, reporter gene expression occurs.