Amy L Marcinkowski

US Patent:

20090053149, Feb 26, 2009

Filed:

Aug 21, 2008

Appl. No.:

12/195544

Inventors:

Tim Corcoran - Pittsburgh PA, US
Amy Lise Marcinkowski - Syracuse NY, US
Joseph Pilewski - Pittsburgh PA, US
Kristina Thomas - Pittsburgh PA, US

International Classification:

A61K 9/12
A61K 31/7036
A61K 31/546
A61K 31/427
A61K 38/12
A61K 31/7052
A61K 31/155
A61K 31/65
A61P 31/10
A61P 31/04
A61P 31/12
A61K 31/5377
A61K 31/407
A61K 31/44
A61K 31/496
A61K 31/351
A61K 31/7048

US Classification:

424 45, 514 40, 514203, 51421015, 514 10, 514 29, 514636, 514152, 5142368, 51421013, 514354, 51425411, 514459, 514 31

Abstract:

A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via inhalation. Thus, when an aerosolized drug solution includes surfactant, Marangoni flows cause the drug particles, once deposited in the lungs, to spread over a wider surface area, thereby ensuring greater antimicrobial efficacy. A solution that contains, for example, an antibiotic and tyloxapol or another surfactant providing a similar surface tension to the composition is optimally delivered by the functional combination of a breath-actuated nebulizer and a high-flow compressor.