Amy S Oliver

US Patent:

6372777, Apr 16, 2002

Filed:

Oct 11, 2000

Appl. No.:

09/686054

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Amy Oliver - Bothell WA
Carmen C. Hertel - Snohomish WA

Assignee:

ICOS Corporation - Bothell WA

International Classification:

A61K 31402

US Classification:

514423, 548531

Abstract:

Pyrrole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

US Patent:

6423710, Jul 23, 2002

Filed:

Nov 21, 2000

Appl. No.:

09/717956

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Joshua Odingo - Everett WA
Edward A. Kesicki - Bothell WA
Amy Oliver - Bothell WA
Laurence E. Burgess - Boulder CO
John J. Gaudino - Longmont CO
Zachary S. Jones - Westminster CO
Bradley J. Newhouse - Broomfield CO
Stephen T. Schlachter - Boulder CO

Assignee:

ICOS Corporation - Bothell WA

International Classification:

A61K 31535

US Classification:

5142315, 51425205, 51425313, 544141, 544372, 548518, 548530, 548579

Abstract:

Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

US Patent:

6458787, Oct 1, 2002

Filed:

May 2, 2001

Appl. No.:

09/847424

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Joshua Odingo - Everett WA
Edward A. Kesicki - Bothell WA
Amy Oliver - Bothell WA
Laurence E. Burgess - Boulder CO
John J. Gaudino - Boulder CO
Zachary S. Jones - Westminster CO
Bradley J. Newhouse - Broomfield CO
Stephen T. Schlacter - Boulder CO

Assignee:

ICOS Corporation - Bothell WA

International Classification:

A61K 31535

US Classification:

5142315, 51425213, 514300, 514367, 544141, 544372, 544335, 5462811, 548518, 548530, 548540

Abstract:

Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

US Patent:

6518277, Feb 11, 2003

Filed:

Apr 24, 2001

Appl. No.:

09/841341

Inventors:

Chanchal Sadhu - Bothell WA
Ken Dick - Bothell WA
Jennifer Treiberg - Bothell WA
C. Gregory Sowell - Mukilteo WA
Edward A. Kesicki - Bothell WA
Amy Oliver - Bothell WA

Assignee:

ICOS Corporation - Bothell WA

International Classification:

A61K 3152

US Classification:

5142661, 5142662, 5142631, 5142632, 5142633, 544264, 544265, 544283, 544319

Abstract:

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K , while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K activity, including compounds that selectively inhibit PI3K activity. Methods of using PI3K inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K inhibitory compounds to inhibit PI3K -mediated processes in vitro and in vivo.

US Patent:

6569885, May 27, 2003

Filed:

Oct 19, 2000

Appl. No.:

09/692364

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Carmen C. Hertel - Snohomish WA
Amy Oliver - Bothell WA

Assignee:

Icos Corporation - Bothell WA

International Classification:

A61K 31415

US Classification:

514403, 514404, 514406

Abstract:

Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

US Patent:

6569890, May 27, 2003

Filed:

Jan 22, 2002

Appl. No.:

10/054273

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Amy Oliver - Bothell WA
Carmen C. Hertel - Snohomish WA

Assignee:

Icos Corporation - Bothell WA

International Classification:

A61K 31402

US Classification:

514423, 548531

Abstract:

Pyrrole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

US Patent:

6667300, Dec 23, 2003

Filed:

Oct 19, 2001

Appl. No.:

10/027591

Inventors:

Chanchal Sadhu - Bothell WA
Ken Dick - Bothell WA
Jennifer Treiberg - Bothell WA
C. Gregory Sowell - Mukilteo WA
Edward A. Kesicki - Bothell WA
Amy Oliver - Bothell WA

Assignee:

ICOS Corporation - Bothell WA

International Classification:

A61K 3133

US Classification:

514183, 5142661, 5142662, 51426623, 5142663, 544283, 544287, 544290

Abstract:

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K , while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K activity, including compounds that selectively inhibit PI3K activity. Methods of using PI3K inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K inhibitory compounds to inhibit PI3K -mediated processes in vitro and in vivo.

US Patent:

6716871, Apr 6, 2004

Filed:

May 17, 2002

Appl. No.:

10/151202

Inventors:

Timothy J. Martins - Bothell WA
Kerry W. Fowler - Seattle WA
Joshua Odingo - Everett WA
Edward A. Kesicki - Bothell WA
Amy Oliver - Bothell WA
Laurence E Burgess - Boulder CO
John J. Gaudino - Longmont CO
Zachary S Jones - Westminster CO
Bradley J Newhouse - Broomfield CO
Stephen T. Schlachter - Boulder CO

Assignee:

Icos Corporation - Bothell WA

International Classification:

A61K 3140

US Classification:

514423, 5142315, 51425211, 514365, 514340

Abstract:

Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.