Andrew Caleb Mercer

US Patent:

20210393802, Dec 23, 2021

Filed:

Nov 13, 2019

Appl. No.:

17/292750

Inventors:

- Rockville MD, US
Subha Karumuthil Melethil - Germantown MD, US
Matthieu Pierre Guibert - Germantown MD, US
Andrew Christopher Mercer - Poolesville MD, US
Micheal James Carrell - Mt. Airy MD, US
Robert Thomas Stadelman - New Market MD, US
Franz Michael Gerner - Myersville MD, US
Nicholas Alexander Piers Sascha Buss - Rockville MD, US
Jared Bee - Gaithersburg MD, US
Tristan James Marshall - Potomac MD, US
Roberto DePaz - Bethesda MD, US

International Classification:

A61K 48/00
A61P 25/00

Abstract:

Provided herein are methods and compositions for treatment of Batten disease. Such compositions include a recombinant adeno-associated virus (rAAV), said rAAV comprising an AAV capsid, and a vector genome packaged therein, said vector genome comprising (a) an AAV 5′ inverted terminal repeat (ITR) sequence; (b) a promoter; (c) a CLN2 coding sequence encoding a human TPP1; (d) an AAV 3′ ITR. Also provided herein are methods of treating Batten disease comprising administering to a subject in need thereof the rAAV described herein via more than one route. Also provide herein are pharmaceutical compositions comprising the rAAV described herein and related methods of treating Batten disease.

US Patent:

20210147854, May 20, 2021

Filed:

Sep 24, 2020

Appl. No.:

17/031149

Inventors:

- La Jolla CA, US
Andrew Mercer - Poolesville MD, US
Brian M. Lamb - San Diego CA, US
Thomas Gaj - Solana Beach CA, US

International Classification:

C12N 15/62
C12N 9/16
C12N 9/22

Abstract:

Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

US Patent:

20180230474, Aug 16, 2018

Filed:

Jan 23, 2018

Appl. No.:

15/878043

Inventors:

- La Jolla CA, US
Andrew Mercer - Poolesville MD, US
Brian M. Lamb - San Diego CA, US
Thomas Gaj - Solana Beach CA, US

International Classification:

C12N 15/62
C12N 9/22
C12N 9/16

Abstract:

Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

US Patent:

20150284728, Oct 8, 2015

Filed:

Sep 4, 2013

Appl. No.:

14/425944

Inventors:

- La Jolla CA, US
Andrew Mercer - Poolesville MD, US
Brian M. Lamb - San Diego CA, US
Thomas Gaj - Solana Beach CA, US

International Classification:

C12N 15/62

Abstract:

Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques. The invention provides a chimeric polypeptide. The polypeptide includes: a) a recombinase, nuclease or transcription factor, or fragment thereof; and b) a transcription activator-like effector (TALE) protein.