Bin Li

US Patent:

20210146003, May 20, 2021

Filed:

Jun 18, 2018

Appl. No.:

16/623024

Inventors:

- Los Angeles CA, US
Mark S. HUMAYUN - Los Angeles CA, US
John WHALEN - Los Angeles CA, US
Niki BAYAT - Los Angeles CA, US
Yi ZHANG - Los Angeles CA, US
Bin LI - Los Angeles CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61L 24/00
A61L 24/02
A61L 24/06
A61L 15/58
A61F 13/02

Abstract:

A temperature-responsive hydrogel includes water, a poly(N-alkylacrylamide) copolymer of a first monomer and a second monomer that is different than the first monomer, and an adhesion-enhancing additive. One type of adhesion-enhancing additive is selected from the group consisting of Arg-Gly-Asp-Ser amino sequence (RGDS), 3-guanidinopropionic acid (GPA), manganese(II) chloride tetrahydrate, and combinations thereof. Characteristically, the temperature-responsive hydrogel has a failure pressure that is at least 2 times greater than a failure pressure for a base temperature-responsive hydrogel having the same composition without the adhesion-enhancing additive. Another type of adhesion-enhancing additive is selected from the family of plant polyphenols, and issued as a priming layer before deployment of the temperature-responsive hydrogel. It not only improves the adhesion of temperature-responsive polymer gels to biological tissues, but also reserves the thermal reversibility of the polymers.