Brad T Stone

US Patent:

20180221464, Aug 9, 2018

Filed:

Aug 3, 2016

Appl. No.:

15/749928

Inventors:

- SEATTLE WA, US
Brad STONE - Seattle WA, US

International Classification:

A61K 39/015
C07K 14/15
A61K 45/06
A61K 47/69
A61P 33/06

Abstract:

An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.