Brent L Podlogar from Hoboken, NJ, age 63

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Position:

Chemisty Professor at TCNJ

Location:

Greater New York City Area

Industry:

Education Management

Work:

TCNJ
Chemisty Professor

Preparation And Use Of 1,5,6,7-Tetrahydropyrrolo[3,2-C]Pyridine Derivatives For Treatment Of Obesity
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US Patent:

7071207, Jul 4, 2006
Filed:

Sep 24, 2002
Appl. No.:

10/487976
Inventors:

Roger A. Smith - Madison CT, US
Stephen J. O'Connor - Guilford CT, US
Wai C. Wong - Trumbull CT, US
Soongyu Choi - Skillman NJ, US
Harold C. Kluender - Trumbull CT, US
Jianmei Fan - Hamden CT, US
Zhonghua Zhang - Derby CT, US
Rico C. Lavoie - Chesire CT, US
Brent L. Podlogar - Flemington NJ, US
Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT
International Classification:

A61K 31/40
A61K 31/395
A61K 31/437
C07D 471/04
C07D 471/14
US Classification:

514300, 514318, 514333, 546113, 5462767, 546289
Abstract:

This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

Methods For Identifying And Using Marr Family Polypeptide Binding Compounds
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US Patent:

7075582, Jul 11, 2006
Filed:

Jul 15, 2002
Appl. No.:

10/196672
Inventors:

Michael N. Alekshun - Wakefield MA, US
Stuart B. Levy - Boston MA, US
Brent L. Podlogar - Hamden CT, US
Roger Frechette - Reading MA, US
Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:

C07D 209/04
US Classification:

348469, 548503, 548494
Abstract:

Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.

Transcription Factor Modulating Compounds And Methods Of Use Thereof
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US Patent:

7405235, Jul 29, 2008
Filed:

Nov 3, 2003
Appl. No.:

10/700661
Inventors:

Stuart B. Levy - Boston MA, US
Michael N. Alekshun - Wakefield MA, US
Brent L. Podlogar - Flemington NJ, US
Kwasi Ohemeng - Norwood MA, US
Atul K. Verma - Mansfield MA, US
Tadeusz Warchol - Northborough MA, US
Beena Bhatia - Mansfield MA, US
Todd Bowser - Charlton MA, US
Mark Grier - Cambridge MA, US
Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:

A61K 31/415
C07D 235/00
US Classification:

514394, 5483044
Abstract:

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e. g. , reducing antibiotic resistance and inhibiting biofilms.

Methods For Identifying And Using Marr Family Polypeptide Binding Compounds
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US Patent:

8039221, Oct 18, 2011
Filed:

Jun 18, 2009
Appl. No.:

12/486972
Inventors:

Michael N. Alekshun - Wakefield MA, US
Stuart B. Levy - Boston MA, US
Brent L. Podlogar - Hamden CT, US
Roger Frechette - Reading MA, US
Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:

G01N 33/53
US Classification:

435 71
Abstract:

Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.

Computational Method For Determining Oral Bioavailability
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US Patent:

20030069721, Apr 10, 2003
Filed:

Sep 10, 2002
Appl. No.:

10/241308
Inventors:

Brent Podlogar - Hamden CT, US
Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:

G06G007/48
G06G007/58
US Classification:

703/011000, 703/012000
Abstract:

A method for determining oral bioavailibility based on the linear regression computer program, SIMCA (Soft Independent Modelling of Class Analogy) is described.

Transcription Factor Modulating Compounds And Methods Of Use Thereof
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US Patent:

20030229065, Dec 11, 2003
Filed:

Aug 14, 2002
Appl. No.:

10/139591
Inventors:

Stuart Levy - Boston MA, US
Michael Alekshun - Wakefield MA, US
Brent Podlogar - Hamden CT, US
Kwasi Ohemeng - Norwood MA, US
Atul Verma - Arlington MA, US
Tadeusz Warchol - Norborough MA, US
Beena Bhatia - Arlington MA, US
International Classification:

A61K031/555
A61K031/505
A61K031/4745
A61K031/47
A61K031/415
A61K031/40
A61K031/407
US Classification:

514/185000, 514/256000, 514/311000, 514/303000, 514/383000, 514/381000, 514/394000, 514/410000, 514/408000
Abstract:

Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.

Methods For Identifying And Using Marr Family Polypeptide Binding Compounds
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US Patent:

20060084678, Apr 20, 2006
Filed:

Dec 7, 2005
Appl. No.:

11/296017
Inventors:

Michael Alekshun - Wakefield MA, US
Stuart Levy - Boston MA, US
Brent Podlogar - Flemington NJ, US
Roger Frechette - Reading MA, US
Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:

G06F 19/00
A61K 31/4704
A61K 31/405
A61K 31/353
A61K 31/343
A61K 31/16
A61K 31/192
US Classification:

514312000, 514414000, 514419000, 514452000, 514568000, 514629000, 548465000, 548510000, 562466000, 562460000, 702019000, 546158000
Abstract:

Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.

Preparation And Use Of 1,5,6,7-Tetrahydropyrrolo[3,2-C]Pyridine Derivatives For The Treatment Of Obesity
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US Patent:

20060122215, Jun 8, 2006
Filed:

Jan 18, 2006
Appl. No.:

11/335349
Inventors:

Roger Smith - Madison CT, US
Stephen O'Connor - Guilford CT, US
Wai Wong - Hamden CT, US
Soongyu Choi - Trumbull CT, US
Harold Kluender - Trumbull CT, US
Jianmei Fan - Hamden CT, US
Zhonghua Zhang - Derby CT, US
Rico Lavoie - Hamden CT, US
Brent Podlogar - Hamden CT, US
Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT
International Classification:

C07D 471/02
A61K 31/4745
US Classification:

514300000, 546113000
Abstract:

This invention relates to 1,5,6,7-tetrahydropynolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

Brent L Podlogar