Catherine L Ellis

US Patent:

6344342, Feb 5, 2002

Filed:

Apr 18, 2001

Appl. No.:

09/837726

Inventors:

Ping Tsui - Berwyn PA
Catherine E. Ellis - Glassboro NJ
Ganesh M. Sathe - King of Prussia PA
Stephanie Van Horn - Pottstown PA
Robert S. Ames - Havertown PA
James J. Foley - Radnor PA
Laura R. Fitzgerald - Kennett Square PA
Henry M. Sarau - Harleyville PA
Jonathan K. Chambers - Hasling Field, GB

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 1512

US Classification:

435 691, 4352523, 4353201, 536 235

Abstract:

HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOFNH30 polypeptides and polynucleotides in terapy, and diagnostic assays for such.

US Patent:

6348585, Feb 19, 2002

Filed:

Jan 3, 2000

Appl. No.:

09/477071

Inventors:

Jeffrey Culp - Collegeville PA
Catherine E Ellis - Glassboro NJ
Dean E McNulty - Philadelphia PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07H 2100

US Classification:

536 2351, 536 231, 536 235, 536 234, 536 243, 536 2431

Abstract:

Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.

US Patent:

6362326, Mar 26, 2002

Filed:

Dec 22, 1998

Appl. No.:

09/218467

Inventors:

Ganesh Sathe - King of Prussia PA
Catherine E. Ellis - Glassboro NJ
Wendy Halsey - Kenneth Square PA
Derk Bergsma - Berwyn PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07H 2104

US Classification:

536 235, 536 231, 4353201, 435325, 435455, 514 44

Abstract:

The present invention relates to 11cby, in particular 11cby polypeptides and 11cby polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinsons disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntingtons disease or Gilles dela Touretts syndrome, hereinafter referred to as âthe Diseasesâ, among others. In a still further aspect, the invention relates to diagnostic and prognostic assays for detecting diseases associated with inappropriate 11cby activity or levels. A method of performing genetic association studies for searching a disease susceptibility and/or drug response genes comprising using polymorphic markers in 11cby polynucleotides.

US Patent:

6506878, Jan 14, 2003

Filed:

Jun 5, 2000

Appl. No.:

09/586924

Inventors:

Catherine E. Ellis - Glassboro NJ
Wendy Halsey - Kennett Square PA
Ganesh M. Sathe - King of Prussia PA
Robert S. Ames - Havertown PA
James J. Foley - Radnor PA
Henry M. Sarau - Harleysville PA
Jon Chambers - Haslingfield, GB

Assignee:

Smithkline Beecham Corporation - Philadelphia PA

International Classification:

C07K 14705

US Classification:

530350, 435 691, 435 711, 435 712, 435325, 435471, 4352523, 43525411, 4353201

Abstract:

HMTMF81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinsons disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntingtons disease or Gilles dela Touretts syndrome, among others and diagnostic assays for such conditions.

US Patent:

20010016336, Aug 23, 2001

Filed:

Jan 19, 2001

Appl. No.:

09/765994

Inventors:

Catherine Ellis - Glassboro NJ, US

International Classification:

A61K038/00
A61K031/70
C12P021/06
C07K001/00
C07K014/00
C07K017/00

US Classification:

435/069100, 530/350000, 435/325000, 514/012000, 514/044000

Abstract:

HFIAO41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFIAO41 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

US Patent:

20010025031, Sep 27, 2001

Filed:

Apr 6, 2001

Appl. No.:

09/828538

Inventors:

Catherine Ellis - Glassboro NJ, US
Cheni Kwok - Hatfield Heath, GB
Nicola Bodsworth - Walden, GB
Wendy Halsey - Kennett Square PA, US
Stephanie Horn - Pottstown PA, US

International Classification:

A61K048/00
C12Q001/68
C07H021/04
C12N005/06
C12P021/02
C07K014/705

US Classification:

514/044000, 435/006000, 435/069100, 435/325000, 530/350000, 536/023500

Abstract:

The invention relates to HFGAN72 receptor polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides and polypeptides, as well as variants thereof, for applications, which relate, in part, to research, diagnostic and clinical arts.

US Patent:

20020038007, Mar 28, 2002

Filed:

Aug 9, 2001

Appl. No.:

09/925776

Inventors:

Robert Ames - Haverford PA, US
Henry Sarau - Harleysville PA, US
James Foley - Radnor PA, US
Derk Bergsma - Berwyn PA, US
Catherine Ellis - Glassboro NJ, US
Jon Chambers - Harlow, GB

International Classification:

C07H021/04
G01N033/53
A61K048/00
A61K038/17
C12N005/06
C12P021/02
C12N015/74

US Classification:

536/023100, 435/007100, 435/325000, 435/455000, 435/069100, 435/320100, 514/044000, 514/012000, 530/388100

Abstract:

Human 11cb splice variant polypeptides and DNA (RNA) encoding such an 11cb splice variant and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such an 11cb splice variant for the treatment of to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome; among others,. Antagonists against such an 11cb splice variant and their use as a therapeutic to treat to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; diabetes; obesity; feeding and drinking abnormalities, such as anorexia and bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome; among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the 11cb splice variant and for detecting altered levels of the polypeptide in a host.

US Patent:

20020048790, Apr 25, 2002

Filed:

Jun 13, 2001

Appl. No.:

09/880261

Inventors:

Winnie Chan - West Chester PA, US
Derk Bergsma - Berwyn PA, US
Catherine Ellis - Glassboro NJ, US

International Classification:

C12P021/02
C12N005/06
C07H021/04
C07K014/705
A61K038/17

US Classification:

435/069100, 435/325000, 530/350000, 536/023500, 514/012000

Abstract:

Human HLTEX11 polypeptides and DNA (RNA) encoding such HLTEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HLTEX11 for the treatment of atherosclerosis, inflammatory conditions, and infections, particularly viral infections, such as AIDS, among others, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HLTEX11 and for detecting altered levels of the polypeptide in a host.