Charles T Mcintyre

US Patent:

6870055, Mar 22, 2005

Filed:

Sep 17, 2001

Appl. No.:

10/362484

Inventors:

David A. Claremon - Maple Glen PA, US
Charles J. McIntyre - Lansdale PA, US
Nigel J. Liverton - Harleysville PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D217/22
C07D217/02
A61K031/47

US Classification:

546141, 546142, 514309, 514307

Abstract:

The present invention concerns certain isoquinolinone compounds and their utility as inhibitors of voltage-dependent potassium channels or currents, such as K1. 5 and I, that could serve as targets for the treatment of cardiac arrhythmias especially atrial arrhythmias. The present invention also provide a method for treating or preventing conditions which respond to the inhibition of potassium channels or currents, such as cardiac arrhythmias and more especially atrial arrhythmias. The present invention further includes pharmaceutical formulations and a process of making a pharmaceutical composition comprising a compound of certain isoquinolinone or its pharmaceutically acceptable salts, hydrates, solvates, crystal forms, and stereoisomers thereof, and a pharmaceutically acceptable carrier.

US Patent:

7723352, May 25, 2010

Filed:

Sep 17, 2004

Appl. No.:

10/571870

Inventors:

B. Wesley Trotter - Glenside PA, US
Christopher Claiborne - Cambridge MA, US
Gerald S. Ponticello - Lansdale NJ, US
Charles J. McIntyre - Lansdale PA, US
Nigel Liverton - Harleysville PA, US
David A. Claremon - Maple Glen PA, US

Assignee:

Merck Sharp & Dohme - Rahway NJ

International Classification:

C07D 471/02
A61K 31/47

US Classification:

514292, 546 94

Abstract:

The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

US Patent:

8338449, Dec 25, 2012

Filed:

Apr 2, 2010

Appl. No.:

12/753572

Inventors:

B. Wesley Trotter - Glenside PA, US
Christopher Claiborne - Cambridge MA, US
Gerald S. Ponticello - Lansdale NJ, US
Charles J. McIntyre - Lansdale PA, US
Nigel Liverton - Harleysville PA, US
David A. Claremon - Maple Glen PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 471/02
A61K 31/47

US Classification:

514292, 514309, 546 94, 546141

Abstract:

The present invention relates to compounds having the structure.