Cheuk K Leung

US Patent:

20130053314, Feb 28, 2013

Filed:

Aug 27, 2012

Appl. No.:

13/595923

Inventors:

Jennifer R. Cochran - Stanford CA, US
Bertrand Howyen Lui - Menlo Park CA, US
Jennifer Lynn Lahti - Half Moon Bay CA, US
James R. Swartz - Menlo Park CA, US
Bob Chen - Stanford CA, US
Cheuk Lun Leung - Stanford CA, US

International Classification:

A61K 38/18
C40B 30/04
G01N 33/566
C07K 14/485

US Classification:

514 96, 530350, 506 9, 436501

Abstract:

Compositions that are EGF polypeptides that possess improved biological activity as compared to the biological activity exhibited by wild-type EGF are provided. Also provided are methods for the preparation of these mutants, methods for the use of these mutants, methods for rationally designing new polypeptide mutants, and methods for screening mutants polypeptides to identify novel EGF mutants with desirable biological activities.