Chin C Liu

US Patent:

6335441, Jan 1, 2002

Filed:

May 30, 2000

Appl. No.:

09/583158

Inventors:

John S. Ng - Chicago IL
Chin Liu - Vernon Hills IL
Dennis K. Anderson - St. Charles MO
Jon P. Lawson - Glencoe MO
Bernhard Erb - Gipf-Oberfrick, CH
Joseph Wieczorek - Cary IL
Sastry A. Kunda - Chesterfield MO
Leo J. Letendre - Manchester MO
Mark J. Pozzo - Chesterfield MO
Yuen-Lung L. Sing - St. Louis MO
Edward E. Yonan - Carol Stream IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

C07J 5300

US Classification:

540 23, 540 15, 552510

Abstract:

Novel 5-cyano steroid compounds including compounds of Formula VII: wherein AâA, BâB, R , R and R are as defined in the specification.

US Patent:

6586591, Jul 1, 2003

Filed:

Aug 31, 2001

Appl. No.:

09/943117

Inventors:

John S. Ng - Chicago IL
Ping T. Wang - Ballwin MO
Julio A. Baez - San Diego CA
Chin Liu - Vernon Hills IL
Dennis K. Anderson - St. Charles MO
Jon P. Lawson - Glencoe MO
Bernhard Erb - Gipf-Oberfrick, CH
Joseph Wieczorek - Cary IL
Gennaro Mucciariello - Rovereto, IT
Fortunato Vanzanella - Naples, IT
Sastry A. Kunda - Chesterfield MO
Leo J. Letendre - Manchester MO
Mark J. Pozzo - Chesterfield MO
Yuen-Lung L. Sing - St. Louis MO
Edward E. Yonan - Carol Stream IL

Assignee:

G.D. Searle Co. - Skokie IL

International Classification:

C07J 2100

US Classification:

540 41, 540 44, 540 76, 549200

Abstract:

A process for the formation of compounds of Formula VI: comprising hydrolyzing a compound corresponding to Formula VII: wherein âAâAâ, âBâBâ, R , R and R are as defined in the specification.

US Patent:

6610844, Aug 26, 2003

Filed:

Mar 29, 2002

Appl. No.:

10/112355

Inventors:

John S. Ng - Chicago IL
Chin Liu - Vernon Hills IL
Dennis K. Anderson - St. Charles MO
Jon P. Lawson - Glencoe MO
Joseph Wieczorek - Cary IL
Sastry A. Kunda - Chesterfield MO
Leo J. Letendre - Manchester MO
Mark J. Pozzo - Chesterfield MO
Yuen-Lung L. Sing - St. Louis MO
Ping T. Wang - Ballwin MO
Edward E. Yonan - Carol Stream IL
Richard M. Weier - Lake Bluff IL
Thomas R. Kowar - Mt. Prospect IL
Julio A. Baez - San Diego CA
Bernhard Erb - Gipf-Oberfrick, CH

Assignee:

G.D. Searle Company - Skokie IL

International Classification:

C07J 2100

US Classification:

540 41, 552638

Abstract:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein âAâAâ represents the group âCHR âCHR â or âCR CR â; R , R and R are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy; R represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical; âBâBâ represents the group âCHR âCHR â or an alpha- or beta-oriented group: where R and R are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R and R are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R and R together comprise a carbocyclic or heterocyclic ring structure, or R or R together with R or comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.

US Patent:

6630587, Oct 7, 2003

Filed:

Aug 7, 2001

Appl. No.:

09/923977

Inventors:

John S. Ng - Chicago IL
Ping T. Wang - Ballwin MO
Julio A. Baez - San Diego CA
Chin Liu - Vernon Hills IL
Dennis K. Anderson - St. Charles MO
Jon P. Lawson - Glencoe MO
Bernhard Erb - Gipf-Oberfrick, CH
Joseph Wieczorek - Cary IL
Gennaro Mucciariello - Rovereto, IT
Fortunato Vanzanella - Napoli, IT
Sastry A. Kunda - Chesterfield MO
Leo J. Letendre - Manchester MO
Mark J. Pozzo - Chesterfield MO
Yuen-Lung L. Sing - St. Louis MO
Edward E. Yonan - Carol Stream IL

Assignee:

G. D. Searle Company - Skokie IL

International Classification:

C07J 900

US Classification:

540 41, 552553

Abstract:

Novel 9-hydroxy steroid compounds, including compounds of Formula IX wherein âAâAâ, âBâBâ, R , R , R and R are as defined in the specification.

US Patent:

6887991, May 3, 2005

Filed:

Aug 25, 2003

Appl. No.:

10/647866

Inventors:

John S. Ng - Chicago IL, US
Chin Liu - Vernon Hills IL, US
Dennis K. Anderson - St. Charles MO, US
Jon P. Lawson - Glencoe MO, US
Joseph Wieczorek - Cary IL, US
Sastry A. Kunda - Chesterfield MO, US
Leo J. Letendre - Manchester MO, US
Mark J. Pozzo - Chesterfield MO, US
Yuen-Lung L. Sing - St. Louis MO, US
Ping T. Wang - Ballwin MO, US
Edward E. Yonan - Carol Stream IL, US
Richard M. Weier - Lake Bluff IL, US
Thomas R. Kowar - Mt. Prospect IL, US
Julio A. Baez - San Diego CA, US
Bernhard Erb - Gipf-Oberfrick, CH

Assignee:

G. D. Searle & Company - Skokie IL

International Classification:

C07J071/00
C07J021/00

US Classification:

540 23

Abstract:

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

US Patent:

6953851, Oct 11, 2005

Filed:

Sep 26, 2003

Appl. No.:

10/672680

Inventors:

John S. Ng - Chicago IL, US
Ping T. Wang - Ballwin MO, US
Julio A. Baez - San Diego CA, US
Chin Liu - Vernon Hills IL, US
Dennis K. Anderson - St. Charles MO, US
Jon P. Lawson - Glencoe MO, US
Bernhard Erb - Gipf-Oberfrick, CH
Joseph Wieczorek - Cary IL, US
Gennaro Mucciariello - Rovereto, IT
Fortunato Vanzanella - Naples, IT
Sastry A. Kunda - Chesterfield MO, US
Leo J. Letendre - Manchester MO, US
Mark J. Pozzo - Chesterfield MO, US
Yuen-Lung L. Sing - St. Louis MO, US
Edward E. Yonan - Carol Stream IL, US

Assignee:

G.D. Searle & Company - Skokie IL

International Classification:

C07J021/00

US Classification:

540 28, 540 41

Abstract:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: —A—A—, —B—B—, R, R, Rand Rare as defined in the specification.

US Patent:

7038040, May 2, 2006

Filed:

Jun 27, 2003

Appl. No.:

10/608101

Inventors:

John S. Ng - Chicago IL, US
Ping T. Wang - Ballwin MO, US
Julio A. Baez - San Diego CA, US
Chin Liu - Vernon Hills IL, US
Dennis K. Anderson - St. Charles MO, US
Jon P. Lawson - Glencoe MO, US
Bernhard Erb - Gipf-Oberfrick, CH
Joseph Wieczorek - Cary IL, US
Gennaro Mucciariello - Rovereto, IT
Fortunato Vanzanella - Naples, IT
Sastry A. Kunda - Chesterfield MO, US
Leo J. Letendre - Manchester MO, US
Mark J. Pozzo - Chesterfield MO, US
Yuen-Lung L. Sing - St. Louis MO, US
Edward E. Yonan - Carol Stream IL, US

Assignee:

G.D. Searle & Co. - St. Louis MO

International Classification:

C07J 71/00
C07D 301/14

US Classification:

540 88, 549528

Abstract:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein:.

US Patent:

7112669, Sep 26, 2006

Filed:

Feb 7, 2005

Appl. No.:

11/052549

Inventors:

John S. Ng - Chicago IL, US
Chin Liu - Vernon Hills IL, US
Dennis K. Anderson - St. Charles MO, US
Jon P. Lawson - Glencoe MO, US
Joseph J. Wieczorek - Cary IL, US
Sastry A. Kunda - Chesterfield MO, US
Leo J. Letendre - Manchester MO, US
Mark J. Pozzo - Portage MI, US
Yuen-Lung L. Sing - St. Louis MO, US
Ping T. Wang - Ballwin MO, US
Edward E. Yonan - Carol Stream IL, US
Richard M. Weier - Lake Bluff IL, US
Thomas R. Kowar - Mt. Prospect IL, US
Julio A. Baez - San Diego CA, US
Bernhard Erb - Gipf-Oberfrick, CH

Assignee:

Pharmacia Corporation (of Pfizer, Inc.) - St. Louis MO

International Classification:

C07J 21/00
C07J 71/00

US Classification:

540 23, 540 44

Abstract:

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.