Christopher Sean Lambert

US Patent:

7935309, May 3, 2011

Filed:

Apr 14, 2006

Appl. No.:

11/404319

Inventors:

W. Grant McGimpsey - Boylston MA, US
Christopher R. Lambert - Hudson MA, US
John S. Benco - Holliston MA, US
Venkat R. Thalladi - Worcester MA, US

Assignee:

Worcester Polytechnic Institute - Worcester MA

International Classification:

G01N 21/62
G01N 21/64
G01N 27/00
G01N 33/00
G01N 33/20
G01N 33/48
G01N 33/50
G01N 33/53
G01N 33/533

US Classification:

422 8208, 422 50, 422 681, 422 8201, 422 8202, 422 8203, 422 8206, 422102, 422103, 422104, 4352872, 436 73, 507136

Abstract:

In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of analyte detection, utilize two transduction mechanisms from the same molecule to determine analyte presence, analyte concentration, or both. An analyte sensing molecule is used that can provide both an optical signal and electrochemical signal when an analyte is recognized by an analyte binding portion of the sensing molecule.

US Patent:

8008088, Aug 30, 2011

Filed:

Jun 26, 2006

Appl. No.:

11/475784

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

G01N 33/00
A61K 49/00

US Classification:

436 95, 436172, 436164, 436518, 436546, 424 96, 424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8029765, Oct 4, 2011

Filed:

Dec 23, 2004

Appl. No.:

10/584821

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8466286, Jun 18, 2013

Filed:

Aug 22, 2011

Appl. No.:

13/215061

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C07F 5/02
A61K 49/00
A61B 5/00
A61B 8/00
A61B 10/00
C07D 471/00

US Classification:

546 13, 546 66, 514288, 514 64, 436 95, 436172, 436164, 424 91, 424 96

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

20020133080, Sep 19, 2002

Filed:

Feb 6, 2002

Appl. No.:

10/066778

Inventors:

William Apruzzese - Everett MA, US
Pierre Trepagnier - Medford MA, US
Russell Gray - Brownsburg IN, US
James Mansfield - Boston MA, US
Christopher Lambert - Hudson MA, US

International Classification:

A61B006/00

US Classification:

600/477000

Abstract:

The invention relates to fluorescence calibration devices and methods that can mimic skin and other tissues. A calibration device of the invention comprises at least one scattering layer, which is preferably non-fluorescent, and a second layer containing one or more fluorophore. Light passes through the scattering layer and excites the fluorophore. Light emitted from the fluorophore passes back though the scattering layer and into collecting optics, which can be measured and that measurement used to correct for instrument drift.

US Patent:

20040106163, Jun 3, 2004

Filed:

Jul 10, 2003

Appl. No.:

10/617915

Inventors:

Jerome Workman - Brookline MA, US
Christopher Lambert - Hudson MA, US

International Classification:

C12Q001/54

US Classification:

435/014000

Abstract:

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatus, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more analytes or parameters found in skin.

US Patent:

20130203145, Aug 8, 2013

Filed:

Mar 8, 2011

Appl. No.:

13/583146

Inventors:

Christopher R. Lambert - Hudson MA, US
W. Grant McGimpsey - Hudson MA, US
Raymond L. Page - Southbridge MA, US
Tanja Dominko - Southbridge MA, US

International Classification:

C12N 13/00

US Classification:

4351731, 4352891

Abstract:

The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell culture.

US Patent:

20140120564, May 1, 2014

Filed:

Aug 12, 2013

Appl. No.:

13/965090

Inventors:

- Irvine CA, US
Christopher R. Lambert - Hudson MA, US
Robert L. Coleman - Olive Hill KY, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C12Q 1/54

US Classification:

435 14, 549227, 4352887

Abstract:

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.