This invention relates to a biotechnology invention concerning human phosphatidic acid phosphatase. More particularly, this invention relates to three variants of human phosphatidic acid phosphatase namely PAP-α(1 and 2), PAP-β and PAP-γ and uses thereof.
Recombinant Production Of Polyanionic Polymers And Uses Thereof
David Leung - Mercer Island WA, US Philip Bergman - Mountlake Terrace WA, US Alan Lofquist - Kirkland WA, US Gregory Pietz - Seattle WA, US Christopher Tompkins - Bothell WA, US David Waggoner - Seattle WA, US
A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
Recombinant Production Of Polyanionic Polymers, And Uses Thereof
David Leung - Mercer Island WA, US Philip Bergman - Mountlake Terrace WA, US Alan Lofquist - Kirkland WA, US Gregory Pietz - Seattle WA, US Christopher Tompkins - Bothell WA, US David Waggoner - Seattle WA, US
A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
Recombinant Production Of Polyanionic Polymers, And Uses Thereof
David W. Leung - Mercer Island WA, US Philip A. Bergman - Mountlake Terrace WA, US Alan Lofquist - Kirkland WA, US Gregory E. Pietz - Seattle WA, US Christopher K. Tompkins - Bothell WA, US David W. Waggoner - Seattle WA, US
International Classification:
C12P 21/00 C07K 1/00 C07K 16/00 C12N 15/64
US Classification:
435 697, 530399, 530351, 5303871, 4353201
Abstract:
A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
David W. Leung - Mercer Island WA Christopher K. Tompkins - Bothell WA
Assignee:
Cell Therapeutics, Inc. - Seattle WA
International Classification:
C12N 920 C12N 120 C12N 1500 C07H 2104
US Classification:
435198
Abstract:
Three new isoforms of phosphatidylcholine phospholipase D, hPLD2. 1, hPLD2. 2 and hPLD1. 5, can be produced recombinantly and are useful for screening compounds, as drug candidates, for an ability to modify PCPLD activity.
David W. Leung - Mercer Island WA James W. West - Seattle WA Christopher K. Tompkins - Bothell WA
Assignee:
Cell Therapeutics, Inc. - Seattle WA
International Classification:
C12N 910 C12Q 148
US Classification:
435 15
Abstract:
There is disclosed cDNA sequences and polypeptides having the enzyme lysophosphatidic acid acyltransferase (LPAAT) activity. LPAAT is also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
David W. Leung - Mercer Island WA James W. West - Seattle WA Christopher K. Tompkins - Bothell WA
Assignee:
Cell Therapeutics, Inc. - Seattle WA
International Classification:
C07H 2104 C12N 910 C12N 912
US Classification:
536 232
Abstract:
There is disclosed cDNA sequences and polypeptides having the enzyme lysophosphatidic acid acyltransferase (LPAAT) activity. LPAAT is also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
Christopher Tompkins (March 24, 1780 - August 9, 1858) was a United States Representative from Kentucky. He was born in Green County, Kentucky where, ...
International Association of Defense Counsel
Member
Betts Patterson Mines
Member of Executive Committee; Head of Complex Litigation Practice Group
Education:
Stanford Law School 1971 - 1974
University of Illinois 1971 - 1971
Bachelors, Bachelor of Arts
University of Illinois
Bachelors, Bachelor of Arts In Business Administration
Skills:
Product Liability Litigation Torts Commercial Litigation Civil Litigation Trials Courts Toxic Tort Class Actions Appeals Public Liability Mediation Trial Practice Business Litigation Wrongful Death Personal Injury Arbitration Legal Research Insurance Medical Malpractice Insurance Law Professional Malpractice Environmental Law Personal Injury Litigation Construction Law Health Law Depositions Dispute Resolution Bad Faith Trade Secrets Automobile Accidents Alternative Dispute Resolution Breach of Contract Jury Trials Litigation Management Professional Liability
Ceo, The Go! Agency And Social Media Marketing Specialist
CEO and Head Social Media Specialist at The Go! Agency
Location:
Seminole, Florida
Industry:
Marketing and Advertising
Work:
The Go! Agency - Seminole, Florida since Jul 2009
CEO and Head Social Media Specialist
Social Media Chef - Online Feb 2009 - Dec 2012
Host and Head Social Media Strategist
XM Radio Show - Clearwater, Florida Oct 2007 - Aug 2009
Senior Producer
EMSI Aug 2007 - Aug 2009
VP of Marketing
The Institute Jan 2004 - Jan 2007
Director of Marketing and Sales
Education:
Imperial College London
Nanjing Institute of Technology
University of Pittsburgh
Skills:
Social Media Marketing Website Design Online Marketing Viral Marketing Email Marketing SEO Blogging Copywriting Web Design Online Advertising Marketing Social Networking YouTube Direct Marketing Web Analytics Facebook Public Relations SEM Newsletters Graphic Design Google Analytics Social Media Press Releases Google Adwords PPC Digital Marketing Web Marketing Advertising Marketing Strategy Brand Development Mobile Marketing Digital Strategy Digital Media Integrated Marketing Content Strategy Social Marketing Website Development SEO copywriting Lead Generation Strategy Competitive Analysis Affiliate Marketing Social Media Strategist Online Reputation Management B2B Marketing CRM Content Marketing Media Buying Social Media Measurement
Interests:
Continuing Education as a Social Media Strategist, Writing, Literature, Design, Online Technology, Music, Health and Fitness, Cooking.
Executive Director At Imat - International Medical Assistance Team
701 Pike St Ste 1400, Seattle, WA 98101 (206)2929988 (Office) 701 Pike St #1400, Seattle, WA 98101 (206)2929988 (Office)
Licenses:
Washington - Active 1981 California - Inactive 1975
Education:
Stanford University School of Law Degree - JD - Juris Doctor - Law Graduated - 1974 University of Illinois Degree - BA - Bachelor of Arts Graduated - 1971
Defense Research Institute - Steering Committee, Drug and Medical Device Litigation Committee International Association of Defense Counsel - Member, Executive Committee Product Liability Advisory Council - Member The Harmonie Group - Memeber
Description:
Mr. Tompkins chairs the Complex Litigation Practice Group and is a member of the Executive Committee at Betts Patterson & Mines. A trial attorney with over 30...
They did not make decisions about Plaintiffs capture, treatment, confinement conditions, and interrogations; and they did not perform, supervise or control Plaintiffs interrogations," defense attorney Christopher Tompkins wrotein court documents.
The variation between the highest- and lowest-cost hospitals can exceed 100%, Robert Mechanic and Christopher Tompkins, PhD, of Brandeis University found. Hospitals spending more than the average spent almost 40% more than those below the average for various episodes.
West Haverstraw Elementary School West Haverstraw NY 1984-1985, Buchanan-Verplanck Elementary School Buchanan NY 1985-1986, Greenwood Lake Elementary School Greenwood Lake NY 1986-1988, Greenwood Lake Middle School Greenwood Lake NY 1988-1988, Blue Mountain Middle School Cortlandt Manor NY 1990-1993