Daniel L Fine

US Patent:

8389015, Mar 5, 2013

Filed:

Mar 15, 2010

Appl. No.:

12/724272

Inventors:

Daniel H. Fine - New York NY, US
David Furgang - East Brunswick NJ, US

Assignee:

University of Medicine and Dentistry of New Jersey - Somerset NJ

International Classification:

A61K 35/12

US Classification:

424520, 424537

Abstract:

The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.

US Patent:

20120115135, May 10, 2012

Filed:

Jul 15, 2011

Appl. No.:

13/183550

Inventors:

Daniel H. Fine - New York NY, US

Assignee:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ

International Classification:

C12Q 1/04
C12Q 1/68

US Classification:

435 611, 435 34

Abstract:

A method for site-specific detection and early diagnosis of periodontal disease using periodontal pocket fluid biomarkers is disclosed.

US Patent:

45157715, May 7, 1985

Filed:

Apr 11, 1983

Appl. No.:

6/483660

Inventors:

Daniel H. Fine - Leonia NJ

International Classification:

A61K 718

US Classification:

424 52

Abstract:

An oral composition for the preventative treatment of dental disease is provided. The composition includes an active ingredient selected from the group consisting of ascorbic acid, pyridoxine hydrochloride, and an anti-inflammatory agent admixed in a vehicle including a gelling agent. Sodium fluoride may also be included. Method and apparatus for dispensing this composition are further provided.

US Patent:

51750899, Dec 29, 1992

Filed:

Jul 15, 1988

Appl. No.:

7/219584

Inventors:

Daniel H. Fine - Leonia NJ
Spyros Vratsanos - Syosset NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12Q 137
C12Q 104
C12Q 106
G01N 33579

US Classification:

435 23

Abstract:

The present invention concerns a method of quantitatively determining the amount of bacterial endotoxin present in a periodontal pocket of a subject. The method comprises: a) obtaining a sample from the periodontal pocket of the subject; b) contacting the sample with an amebocyte lysate under conditions so as to activate an enzyme capable of cleaving a bond between an arginyl group and a nitrogen-containing group; c) contacting the activated enzyme with a substrate comprising an arginyl group and a suitable nitrogen-containing group bound to the arginyl group so as to form an amine; d) treating the resulting amine to produce a detectable product; and e) quantitatively determining the amount of product formed and thereby the amount of bacterial endotoxins present in the periodontal pocket. The invention also provides a method of diagnosing a periodontal disease which comprises quantitatively determining the amount of bacterial endotoxins present in a periodontal pocket of a subject by the method of the present invention and correlating the amount so determined with known periodontal disease-causing amounts of endotoxin.

US Patent:

50948415, Mar 10, 1992

Filed:

Jul 5, 1988

Appl. No.:

7/214755

Inventors:

Daniel H. Fine - Leonia NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 718

US Classification:

424 52

Abstract:

The present invention concerns a gel composition useful for treating or preventing caries of the root which comprises sodium fluoride and an antibacterial agent in concentrations sufficient to retard or prevent caries of the root and a gel carrier. In the most preferred embodiment, the gel composition further comprises preservatives and taste agents and contains a gel carrier which comprises a combination of gum tragacanth, gum arabic and agar-agar.

US Patent:

52982378, Mar 29, 1994

Filed:

Jan 24, 1992

Appl. No.:

7/826482

Inventors:

Daniel H. Fine - Leonia NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 716
A61K 31375
A61K 3334

US Classification:

424 49

Abstract:

The present invention provides a gel composition useful for the prevention or treatment of gingivitis, periodontal disease, and dental plaque which comprises ascorbic acid, copper sulfate, and essentially no added oxidizing agent, in concentrations sufficient for the prevention or treatment of gingivitis, periodontal disease, and dental plaque; and a gel carrier. The invention also provides a method for the prevention or treatment of gingivitis, periodontal disease, and dental plaque in the oral cavity of a subject which comprises applying for an effective period of time within the oral cavity of a subject an amount of the gel composition effective to prevent or treat gingivitis, periodontal disease, and dental plaque.

US Patent:

20140194344, Jul 10, 2014

Filed:

Apr 23, 2012

Appl. No.:

14/113245

Inventors:

Daniel H. Fine - New York NY, US
Kabilan Velliyagounder - Monmouth Junction NJ, US

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61K 38/16
C07K 14/00
A23L 1/305
A61K 45/06

US Classification:

514 24, 530324, 536 234

Abstract:

The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and PAK fusion peptides (PAK-LF), along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.