Daniel R Kagan

US Patent:

20130084569, Apr 4, 2013

Filed:

Mar 28, 2011

Appl. No.:

13/637645

Inventors:

Joseph Wang - San Diego CA, US
Jie Wu - Nanjing, CN
Shankar Balasubramanian - Acton MA, US
Daniel Kagan - Westfield NJ, US
Kalayil Manian Manesh - San Diego CA, US

International Classification:

C12Q 1/68
C12N 15/115
C07K 17/14
G01N 33/558
G01N 33/58

US Classification:

435 611, 435 613, 436501, 435 79, 435188, 5303913, 536 2431, 977726, 977773, 977920

Abstract:

Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine.

US Patent:

20140045179, Feb 13, 2014

Filed:

Jan 31, 2012

Appl. No.:

13/983034

Inventors:

Joseph Wang - San Diego CA, US
Shankar Balasubramanian - Acton MA, US
Daniel Kagan - Westfield NJ, US
Susana Campuzano-Ruiz - Madrid, ES

International Classification:

C12Q 1/68
G01N 1/10

US Classification:

435 611, 4353091, 435 30, 435 612

Abstract:

Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to include a large opening and a small opening that are on opposite ends of the tube, and a tube body connecting the openings and having a cross section spatially reducing in size from the large opening to the small opening, in which the tube includes a layered wall including an inner layer having a catalyst material that is reactive with a fuel fluid to produce bubbles exiting the tube from the large opening to propel the tube to move in the fuel fluid and an external layer formed of a material capable of being functionalized, and a molecular layer functionalized onto the external layer of the tube and structured to attach to a targeted molecule in the fuel fluid.

US Patent:

20150013304, Jan 15, 2015

Filed:

Feb 19, 2013

Appl. No.:

14/379279

Inventors:

- Oakland CA, US
Sadik C. Esener - Solana Beach CA, US
Daniel Kagan - Westfield NJ, US
Michael Benchimol - San Diego CA, US
Jonathan Claussen - San Diego CA, US

International Classification:

F02K 7/02
A61M 37/00

US Classification:

60204, 60770

Abstract:

Techniques, devices and systems are disclosed for implementing acoustically triggered propulsion of nano- and micro-scale structures. In one aspect, an ultrasound responsive propulsion device includes a tube that includes one or more layers including an inner layer having an electrostatic surface, and an ultrasound-responsive substance coupled to the inner layer and configured to form gaseous bubbles in a fluid in response to an ultrasound pulse, in which the bubbles exit the tube to propel the tube to move in the fluid.