Dennis Duane Johnston

US Patent:

60701269, May 30, 2000

Filed:

Jun 12, 1998

Appl. No.:

9/097078

Inventors:

William J. Kokolus - Kenmore NY
Herbert A. Fritsche - Houston TX
Dennis A. Johnston - Houston TX

International Classification:

C07K 1400

US Classification:

702 19

Abstract:

The present invention relates to identifying protein epitopes and more particularly to a novel method for identifying, determining the location, optimal length of amino acid residues and immunobiological potency of protein epitopes by applying a custom negative cosine function fit algorithm to a protein hydropathy scale. This fit analysis is supplemented with experimental immunobiological data. The amino acid sequence of the protein epitopes of the present invention exhibit a hydrophobic-hydrophilic-hydrophobic hydropathy pattern of an approximately fixed length in a given protein.

US Patent:

63264714, Dec 4, 2001

Filed:

Sep 4, 1998

Appl. No.:

9/146831

Inventors:

William J. Kokolus - Kenmore NY
Herbert A. Fritsche - Houston TX
Dennis A. Johnston - Houston TX

International Classification:

C07K 1618
C07K 1606
C07K 1630
C07K 1640
C07K 708

US Classification:

5303879

Abstract:

Peptides derived from prostate specific antigen (PSA) that correspond to the immunodominant epitopes found in the native antigen are disclosed. These peptides were identified using a method that predicts continuous, immunodominant epitopes. Anti-PSA antibodies, methods for their production and their use in diagnostic assays also are disclosed.