Derek Thomas Lowe

US Patent:

6660752, Dec 9, 2003

Filed:

Apr 22, 2002

Appl. No.:

10/131448

Inventors:

Stephen J. OConnor - Guilford CT
Gaetan H. Ladouceur - Branford CT
William H. Bullock - Easton CT
Ann-Marie Campbell - Monroe CT
Miao Dai - Briarwood NY
Robert Dally - Indianapolis IN
Jacques Dumas - Bethany CT
Holia N. Hatoum-Mokdad - Hamden CT
Uday Khire - Hamden CT
Wendy Lee - Hamden CT
Qingjie Liu - Milford CT
Derek B. Lowe - Hamden CT
Steven R. Magnuson - Hamden CT
Ning Qi - Hamden CT
Tatiana E. Shelekhin - Ridgefield CT
Quanrong Shen - Fishers IN
Roger A. Smith - Madison CT
Ming Wang - Milford CT

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 3144

US Classification:

514337, 5462827

Abstract:

This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

US Patent:

6784167, Aug 31, 2004

Filed:

Sep 28, 2001

Appl. No.:

09/967430

Inventors:

Jill E. Wood - North Haven CT
Jeremy L. Baryza - Mountain View CA
Catherine R. Brennan - Hamden CT
Soongyu Choi - Trumbull CT
James H. Cook - East Hampton CT
Brian R. Dixon - Woodbridge CT
Paul P. Ehrlich - Duesseldorf-Wittlaer, DE
David E. Gunn - Hamden CT
Ian McAlexander - Pocatello ID
Peiying Liu - Madison CT
Derek B. Lowe - Hamden CT
William J. Scott - Guilford CT
Yamin Wang - Sandy Hook CT

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 3140

US Classification:

514 63, 5142278, 5142372, 51425401, 514274, 514314, 514343, 514365, 514411, 514414, 514422, 514424, 544 582, 544 587, 544 60, 544141, 544316, 544372, 546167, 5462784, 548204, 548205, 548406, 548450, 548468, 548517, 548518, 548525, 548526, 548527, 548551

Abstract:

17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group âC(R )(R )Y are oriented cis to each other; W represents O or S; R represents âH or optionally substituted â(C -C )alkyl; n represents 0 or an integer of 1-3; and R represents any of a variety of substituents on ring A. R generally represents âH but may be a bond terminating at the ortho position of ring A. Y represents fluorine, âOR , or âSR , and R represents âH, optionally substituted â(C -C )alkyl, optionally substituted -phenyl, optionally substituted â(C -C )alkyl-phenyl, or optionally substituted â(C -C )acyl. R represents any of a variety of groups as defined in the specification and claims, including heteroaryl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, alkynyl, arylalkynyl, heteroarylalkynyl, aryl, and indolyl. Pharmaceutically acceptable salts and N-oxides of these materials are also included.

US Patent:

6787651, Sep 7, 2004

Filed:

Oct 9, 2001

Appl. No.:

09/974319

Inventors:

Andreas Stolle - Leverkusen, DE
Jacques P. Dumas - Bethany CT
William Carley - La Jolla CA
Philip D. G. Coish - New Haven CT
Steven R. Magnuson - Hamden CT
Yamin Wang - Sandy Hook CT
Dhanapalan Nagarathnam - Bethany CT
Derek B. Lowe - Hamden CT
Ning Su - Hamden CT
William H. Bullock - Easton CT
Ann-Marie Campbell - Monroe CT
Ning Qi - Hamden CT
Jeremy L. Baryza - Mountain View CA
James H. Cook - East Hampton CT

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D20934

US Classification:

544143, 544373, 546176, 548159, 548181, 548222, 548425, 548430, 548464, 548466, 548467, 548492

Abstract:

Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR- mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.

US Patent:

6828335, Dec 7, 2004

Filed:

Jul 25, 2002

Appl. No.:

10/205839

Inventors:

Derek B. Lowe - Hamden CT
Philip L. Wickens - Wallingford CT
Xin Ma - Bethany CT
Mingbao Zhang - Stamford CT
William H. Bullock - Easton CT
Philip D. G. Coish - New Haven CT
Ingo A. Mugge - New Haven CT
Andreas Stolle - Wuppertal, DE
Ming Wang - Milford CT
Yamin Wang - Sandy Hook CT
Chengzhi Zhang - Orange CT
Hai-Jun Zhang - Middletown CT
Lei Zhu - Milford CT
Manami Tsutsumi - Stratford CT
James N. Livingston - Guilford CT

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 31421

US Classification:

514340, 514374, 514365, 5462714, 548235, 548236, 548203

Abstract:

This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

US Patent:

6919371, Jul 19, 2005

Filed:

Sep 17, 2003

Appl. No.:

10/666903

Inventors:

Stephen J. O'Connor - Guilford CT, US
Gaetan H. Ladouceur - Branford CT, US
William H. Bullock - Easton CT, US
Ann-Marie Campbell - Monroe CT, US
Miao Dai - Briarwood NY, US
Robert Dally - Indianapolis IN, US
Jacques Dumas - Bethany CT, US
Holia N. Hatoum-Mokdad - Hamden CT, US
Uday Khire - Hamden CT, US
Wendy Lee - Hamden CT, US
Qingjie Liu - Milford CT, US
Derek B. Lowe - Hamden CT, US
Steven R. Magnuson - Hamden CT, US
Ning Qi - Hamden CT, US
Tatiana E. Shelekhin - Ridgefield CT, US
Quanrong Shen - Fishers IN, US
Roger A. Smith - Madison CT, US
Ming Wang - Milford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K031/352
C07D311/58

US Classification:

514456, 5462821, 5462827, 549398, 549404, 514337

Abstract:

This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

US Patent:

7112597, Sep 26, 2006

Filed:

Sep 22, 2004

Appl. No.:

10/949119

Inventors:

Derek B. Lowe - Hamden CT, US
Philip L. Wickens - Wallingford CT, US
Xin Ma - Bethany CT, US
Mingbao Zhang - Stamford CT, US
William H. Bullock - Easton CT, US
Philip D. G. Coish - New Haven CT, US
Ingo Mugge - New Haven CT, US
Andreas Stolle - Wuppertal, DE
Ming Wang - Milford CT, US
Yamin Wang - Sandy Hook CT, US
Chengzhi Zhang - Orange CT, US
Hai-Jun Zhang - Middletown CT, US
Lei Zhu - Milford CT, US
Manami Tsutsumi - Stratford CT, US
James N. Livingston - Guilford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

A61K 31/425
C07D 277/30

US Classification:

514365, 548203

Abstract:

This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

US Patent:

7358386, Apr 15, 2008

Filed:

May 5, 2006

Appl. No.:

11/429136

Inventors:

Derek B. Lowe - Hamden CT, US
Philip L. Wickens - Wallingford CT, US
Xin Ma - Bethany CT, US
Mingbao Zhang - Stamford CT, US
William H. Bullock - Easton CT, US
Philip D. G. Coish - New Haven CT, US
Ingo Mugge - New Haven CT, US
Andreas Stolle - Wuppertal, DE
Ming Wang - Milford CT, US
Yamin Wang - Sandy Hook CT, US
Chengzhi Zhang - Orange CT, US
Hai-Jun Zhang - Middletown CT, US
Lei Zhu - Milford CT, US
Manami Tsutsumi - Stratford CT, US
James N. Livingston - Guilford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West haven CT

International Classification:

C07C 69/76
C07C 59/00
C07D 277/20
C07D 413/00

US Classification:

560102, 562461, 562462, 548202, 548235

Abstract:

This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

US Patent:

8431695, Apr 30, 2013

Filed:

Nov 2, 2006

Appl. No.:

12/084411

Inventors:

Stephen O'Connor - Guilford CT, US
Jacques Dumas - Carlisle MA, US
Wendy Lee - San Ramon CA, US
Julie Dixon - Bethany CT, US
David Cantin - Hamden CT, US
David Gunn - Hamden CT, US
Jennifer Burke - Newtown CT, US
Barton Phillips - New Haven CT, US
Derek Lowe - Acton MA, US
Tatiana Shelekhin - Ridgefield CT, US
Gan Wang - Wallingford CT, US
Xin Ma - Haan, DE
Shihong Ying - Orange CT, US
Andrea McClure - West Haven CT, US
Furahi Achebe - West Haven CT, US
Mario Lobell - Wuppertal, DE
Frederick Ehrgott - Killingworth CT, US
Christiana Iwuagwu - Hamden CT, US
Kyle Parcella - Wallingford CT, US

Assignee:

Bayer Intellectual Property GmbH - Monheim

International Classification:

C07D 487/04
C07D 413/02
C07D 417/02
A61K 31/53
A61P 35/00

US Classification:

544183, 514243

Abstract:

This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.