Dong M Liang

US Patent:

20070281900, Dec 6, 2007

Filed:

May 2, 2007

Appl. No.:

11/743480

Inventors:

Kunyuan Cui - Bothell WA, US
Dong Liang - Bothell WA, US
David S. Sweedler - Louisville CO, US

Assignee:

NASTECH PHARMACEUTICAL COMPANY INC. - Bothell WA

International Classification:

A61K 48/00
C12N 15/88

US Classification:

514 44, 435458

Abstract:

A composition of an interfering RNA comprising a double-stranded RNA (dsRNA) molecule having a double-stranded region of from about 15 to about 40 base pairs, a peptide having a hydrophobic region and a cationic region, and a non-cationic phospholipid, and uses thereof.

US Patent:

20070293449, Dec 20, 2007

Filed:

Jun 20, 2007

Appl. No.:

11/766038

Inventors:

Kunyuan Cui - Bothell WA, US
Roger Adami - Snohomish WA, US
Dong Liang - Everett WA, US

Assignee:

NASTECH PHARMACEUTICAL COMPANY INC. - Bothell WA

International Classification:

A61K 48/00
C12N 15/88

US Classification:

514044000, 435458000

Abstract:

Pharmaceutical compositions and methods of use of a composition containing a double-stranded RNA (dsRNA), cationic lipids, non-cationic lipids, and lipophilic delivery-enhancing compounds.

US Patent:

20100022618, Jan 28, 2010

Filed:

Sep 5, 2008

Appl. No.:

12/231900

Inventors:

Dong Liang - Everett WA, US
David Sweedler - Louisville CO, US
Kunyuan Cui - Botthell WA, US

International Classification:

A61K 31/713
C12N 15/113

US Classification:

514 44 A, 536 245

Abstract:

Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.

US Patent:

20120286389, Nov 15, 2012

Filed:

May 11, 2012

Appl. No.:

13/470195

Inventors:

Anjia Gu - Menlo Park CA, US
Yijie Huo - Mountain View CA, US
Dong Liang - Stanford CA, US
Yangsen Kang - Stanford CA, US

International Classification:

H01L 31/0236

US Classification:

257466, 257E3113, 977954

Abstract:

Photovoltaic devices conformally deposited on a nano-structured substrate having hills and valleys have corresponding hills and valleys in the device layers. We have found that disposing an insulator in the valleys of the device layers such that the top electrode of the device is insulated from the device layer valleys provides beneficial results. In particular, this insulator prevents electrical shorts that otherwise tend to occur in such devices.

US Patent:

20120289584, Nov 15, 2012

Filed:

May 16, 2010

Appl. No.:

13/320901

Inventors:

Kunyuan Cui - Bothell WA, US
Dong Liang - Everett WA, US
David Sweedler - Seattle WA, US

Assignee:

AGAVE PHARMA, INCORPORATED - Seattle WA

International Classification:

A61K 31/7088
C07H 21/02
A61P 35/00
A61P 1/16
A61P 11/00
C07H 21/00
C07H 21/04

US Classification:

514 44 R, 536 231, 536 245

Abstract:

This disclosure provides compositions that are useful combined with therapeutics, and in the diagnosis and treatment of diseases and conditions. The compositions are useful for delivery of agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

US Patent:

20150047702, Feb 19, 2015

Filed:

Nov 3, 2014

Appl. No.:

14/531492

Inventors:

- Palo Alto CA, US
Yijie Huo - Cupertino CA, US
Dong Liang - Fremont CA, US
Yangsen Kang - Stanford CA, US

International Classification:

H01L 31/0236
H01L 31/0352

US Classification:

136256

Abstract:

Photovoltaic devices conformally deposited on a nano-structured substrate having hills and valleys have corresponding hills and valleys in the device layers. We have found that disposing an insulator in the valleys of the device layers such that the top electrode of the device is insulated from the device layer valleys provides beneficial results. In particular, this insulator prevents electrical shorts that otherwise tend to occur in such devices.