Edward Darnell Murray

US Patent:

7786287, Aug 31, 2010

Filed:

Apr 11, 2003

Appl. No.:

10/510912

Inventors:

Osvaldo A. Flores - North Wales PA, US
Jay Grobler - Gwynedd PA, US
Edward M. Murray - Limerick PA, US
Paul D. Zuck - Trenton NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07H 21/00
C12P 21/00
C12N 15/00
C12N 15/51
C12N 7/00

US Classification:

536 2372, 435 691, 4352351, 4353201

Abstract:

The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3′ UTR based on the HCV-1a 3′ UTR. These features can be employed alone or together, and are preferably combined together to measure HCV replicon activity and the affect of compounds on such activity.

US Patent:

61875481, Feb 13, 2001

Filed:

May 23, 1996

Appl. No.:

8/652877

Inventors:

Goran Akerstrom - Uppsala, SE
Claes Juhlin - Uppsala, SE
Lars Rask - Uppsala, SE
Goran Hjalm - Uppsala, SE
Clarence C. Morse - Royersford PA
Edward M. Murray - Drexel Hill PA
Gregg R. Crumley - Philadelphia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

G01N 3353
G01N 33567

US Classification:

435 72

Abstract:

The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.

US Patent:

62392700, May 29, 2001

Filed:

Jun 7, 1995

Appl. No.:

8/476515

Inventors:

Goran Akerstrom - Uppsala, SE
Claes Juhlin - Uppsala, SE
Lars Rask - Uppsala, SE
Goran Hjalm - Uppsala, SE
Clarence C. Morse - Royersford PA
Edward M. Murray - Drexel Hill PA
Gregg R. Crumley - Philadelphia PA

Assignee:

Rhone-Poulenc Rorer S.A. - Antony

International Classification:

A61K 317105
A61K 31711
C07H 2104

US Classification:

536 243

Abstract:

The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.