Edward J O'Connor

US Patent:

53627288, Nov 8, 1994

Filed:

Jul 29, 1992

Appl. No.:

7/915710

Inventors:

Theodros Asberom - Morris Plains NJ
Edward O'Connor - Hoboken NJ
Joel G. Berger - Cedar Grove NJ
John W. Clader - Cranford NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3155
C07D22318
C07D22332

US Classification:

514217

Abstract:

Novel benzazepines of the formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R represents H, alkyl, allyl or ##STR2## A represents --[CR. sup. 1 R. sup. 2]. sub. n --; n represents 3 or 4; R. sup. 1 and R. sup. 2 may be the same or different and each independently represents H, OH, atkyl, alkoxy, phnenyl or substituted phenyl, with the proviso that R. sup. 1 and R. sup. 2 on the same carbon atom are not both OH, or R. sup. 1 and R. sup. 2 on the same carbon atom together represent=O; G represents H, R. sup. 3 (CO)-- or ArNHCO--; R. sup. 3 represents H, alkyl, alkoxy, phenyl or substituted phenyl; Ar represents phenyl or substituted phenyl; and Y and Z may be the same or different and each is independently selected from H, halo, alkyl, alkoxy or halpalkyl; the pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, useful in the treatment of psychoses, drug dependence, D1 dependent neurological disorder or pain are disclosed.