Eric D Cline

US Patent:

20080090865, Apr 17, 2008

Filed:

Jan 24, 2006

Appl. No.:

11/794591

Inventors:

Min Ge - Edison NJ, US
Lihu Yang - Edison NJ, US
Changyou Zhou - Princeton NJ, US
Songnian Lin - Monroe NJ, US
Eric Cline - Princeton NJ, US

International Classification:

A61K 31/47
A61K 31/435
A61P 3/10
C07D 215/00
C07D 221/02

US Classification:

514312000, 514299000, 546153000, 546183000

Abstract:

Bicyclic compounds containing a fused pyridine ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

US Patent:

20090253673, Oct 8, 2009

Filed:

Jul 6, 2007

Appl. No.:

12/227545

Inventors:

Min Ge - Edison NJ, US
Eric Cline - Princeton NJ, US
Lihu Yang - Edison NJ, US
Sander G. Mills - Scotch Plains NJ, US

International Classification:

A61K 31/4155
C07D 403/06
C07D 401/06
C07D 231/12
C07D 231/38
C07D 413/12
C07D 417/12
A61K 31/415
A61K 31/454
A61K 31/496
A61K 31/4178
A61K 31/422
A61K 31/4245
A61K 31/4439
A61K 31/497
A61K 31/506
A61K 31/427
A61P 3/04
A61P 3/10

US Classification:

5142102, 5483641, 546211, 544371, 5483741, 5483647, 5483717, 548236, 5462754, 544333, 548200, 514406, 514326, 51425405, 514407, 514397, 514374, 514364, 514341, 51425505, 514256, 514365

Abstract:

Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of the ghrelin receptor, such as obesity, diabetes, and metabolic syndrome.

US Patent:

20090312303, Dec 17, 2009

Filed:

Jan 30, 2006

Appl. No.:

11/794705

Inventors:

Min Ge - Edison NJ, US
Lihu Yang - Edison NJ, US
Changyou Zhou - Princeton NJ, US
Songnian Lin - Monroe NJ, US
Haifeng Tang - Metuchen NJ, US
Eric Dean Cline - Princeton NJ, US
Sunita Malkani - Lincoln Park NJ, US

Assignee:

MERCK & CO., INC. - Rahway NJ

International Classification:

A61K 31/427
C07D 277/04
C07D 417/12
C07D 263/04
A61K 31/4439
A61K 31/4709
A61K 31/422
A61K 31/397
A61P 3/10

US Classification:

51421018, 548183, 5462697, 546141, 548226, 514369, 514342, 514309, 514376

Abstract:

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.