Eric Albert Meade

US Patent:

61037435, Aug 15, 2000

Filed:

Aug 6, 1999

Appl. No.:

9/369686

Inventors:

Stanley Charles Bell - Narberth PA
Kathleen Da Silva - Ontario, CA
Allen Hopper - Somerset NJ
Methvin Isaac - Ontario, CA
Eric A. Meade - Fanwood NJ
Vassil Ilya Ognyanov - Princeton NJ
Abdelmalik Slassi - Ontario, CA

Assignee:

Allelix Neuroscience, Inc. - Salt Lake City UT

International Classification:

A61K 3144
A61K 31195
A61K 3124
A61K 3121
A61K 3138

US Classification:

514357

Abstract:

Described herein are compounds having the general formula: ##STR1## Ar. sub. 1 and Ar. sub. 2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO. sub. 2, Ph, CF. sub. 3, CN, OH, methylenedioxy, ethylenedioxy, SO. sub. 2 NRR', NRR', CO. sub. 2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above; wherein any cycloalkyl or aryl substituent is linked to Ar. sub. 1 or Ar. sub. 2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH. sub. 2). sub. n -- group, a --(CH. sub. 2). sub. n --Z-- group, or a --Z--(CH. sub. 2). sub.

US Patent:

61628247, Dec 19, 2000

Filed:

Jul 30, 1999

Appl. No.:

9/365070

Inventors:

Vassil I. Ognyanov - Princeton NJ
Allen Hopper - Somerset NJ
Stanley Charles Bell - Narberth PA
Eric A. Meade - Fanwood NJ
Michael De Vivo - New York NY

Assignee:

Allelix Neuroscience Inc.

International Classification:

A61K 3138
A61K 31195
C07D33322
C07C21100

US Classification:

514438

Abstract:

Described herein are compounds which have the general formula: ##STR1## or a prodrug or pharmaceutically acceptable salt, solvate or hydrate thereof wherein: R. sup. 1 is selected from the group consisting of H, alkyl and the counter ion for a basic addition salt; X is selected from the group consisting of CR. sup. 9 R. sup. 10, S, O, SO, SO. sub. 2, NH and N-alkyl; R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 9 and R. sup. 10 are independently selected from the group consisting of H and alkyl; R. sup. 5 and R. sup. 6 are independently selected from the group consisting of H, alkyl and phenyl, or, alternatively, R. sup. 5 and R. sup. 6 together may form a methylene group or a 3- to 6-membered a spirocyclic group; wherein, when X is CR. sup. 9 R. sup. 10, one or both pairs of R. sup. 5 and R. sup. 9 or R. sup. 6 and R. sup. 10 may join to form a double or triple bond R. sup.