Feng E Gao

US Patent:

6541263, Apr 1, 2003

Filed:

Feb 21, 2001

Appl. No.:

09/788353

Inventors:

Feng Gao - Stamford CT

Assignee:

Euro-Celtique, S.A. Luxembourg

International Classification:

G01N 3392

US Classification:

436 71, 436101, 436173, 436139

Abstract:

The present invention is directed to a method of detecting a corticosteroid in a sample by adding an internal standard to a sample suspected of containing a corticosteroid; removing interfering compounds from the sample; placing the sample on an HPLC column equilibrated with a NH OAc:MeOH solution and collecting an eluent; and analyzing the eluent of the HPLC column with a MS, wherein if contained in the sample, the corticosteroid forms an adduct that is detected by the MS.

US Patent:

6740641, May 25, 2004

Filed:

Jul 22, 2002

Appl. No.:

10/199526

Inventors:

Feng Gao - Stamford CT
Jahanara Miotto - Carmel NY

Assignee:

Euro-Celtique, S.A.

International Classification:

A01N 4304

US Classification:

514 27, 514281, 514282, 546 44, 546 45, 546 46, 424 7829

Abstract:

Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof; and methods for treating or preventing pain in a patient comprising administering to a patient in need thereof a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof are disclosed.