Frank E Block

US Patent:

58301852, Nov 3, 1998

Filed:

Oct 12, 1995

Appl. No.:

8/542424

Inventors:

Frank E. Block - Little Rock AR

Assignee:

Instrumentarium Corp.

International Classification:

A61M 100

US Classification:

604122

Abstract:

A position-independent fluid trap for separating at least a portion of a first fluid of a first density entrained within a flow stream of a second fluid of a second density flowing through a fluid circuit. The trap is connectable within the fluid circuit to a first length of tubing defining an inlet line and to a second length of tubing defining an outlet line, and includes a housing enclosing an interior chamber having a geometric extent of a given volumetric capacity. An inlet port is provided to open in fluid communication with the interior chamber and to be couplable to the inlet line. An outlet tube is provided to extend from a proximal end couplable to the outlet line to a distal end disposed within the housing and opening in fluid communication with the interior chamber. Within the interior chamber, the first and second fluid are separated at an interface into a first and second fluid component according to the relative densities thereof. The outlet line distal end is disposed within the chamber effective to define with respect to the interface a predetermined fill volume of the second fluid maintaining the outlet line distal end within the second fluid component.

US Patent:

62131206, Apr 10, 2001

Filed:

Aug 21, 1997

Appl. No.:

8/916062

Inventors:

Frank E. Block - Little Rock AR
Gustaf Jarnefelt - Helsinki, FI

Assignee:

Instrumentarium Corporation - Helsinki

International Classification:

A61M 1600

US Classification:

12820423

Abstract:

A detector for determining the volume and volumetric changes of respiratory gases in a closed circuit anaesthesia circuit having a bellows ventilator. The device includes a first sensor positioned with respect to the bellows for detecting and indicating when the bellows assumes a given expanded position in a bellows housing indicative of the given volume of respiratory gas in the circuit. A second sensor detects and indicates when the bellows assumes an expanded position indicative of the greater amount of expansion than that corresponding to the given expanded position. During respiratory cycles of the patient, indications from the first sensor in the absence of indications from the second sensor indicates that the volume of gas in the closed circuit anaesthesia circuit is not changing, but is remaining at that corresponding to the given expanded position of the bellows. Indications from both the first sensor and the second sensor indicates that the degree of expansion of the bellows is greater than that corresponding to the given expanded position and hence the volume of gas in the closed circuit anaesthesia circuit has increased. The absence of indications from both the first and second sensors indicates that the degree of expansion of the bellows is less than that corresponding to the given expanded position and that the volume of gas in the closed circuit anaesthesia circuit has decreased.

US Patent:

20190064144, Feb 28, 2019

Filed:

Jul 30, 2018

Appl. No.:

16/049025

Inventors:

- Nashville TN, US
David E. Cliffel - Nashville TN, US
Dmitry A. Markov - Nashville TN, US
John A. McLean - Nashville TN, US
Lisa Joy McCawley - Nashville TN, US
Phillip C. Samson - Nashville TN, US
Ronald S. Reiserer - Nashville TN, US
Frank Emmanuel Block - Nashville TN, US
Jennifer Robin McKenzie - Nashville TN, US

International Classification:

G01N 33/50
A01N 1/02
B01L 3/00

Abstract:

A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.

US Patent:

20150298123, Oct 22, 2015

Filed:

Nov 20, 2013

Appl. No.:

14/646300

Inventors:

- Nashville TN, US
Philip C. Samson - Nashville TN, US
Erik M. Werner - Nashville TN, US
Dmitry A. Markov - Nashville TN, US
Ronald S. Reiserer - Nashville TN, US
Jennifer R. Mckenzie - Antioch TN, US
David E. Cliffel - Nashville TN, US
William J. Matloff - Paradise Valley AR, US
Frank E. Block - Nashville TN, US
Joseph R. Scherrer - Nashville TN, US
W. Hunter Tidwell - Nashville TN, US
John P. Wikswo - Brentwood TN, US

International Classification:

B01L 3/00
C12M 3/06
C12M 1/00
C12M 3/00

Abstract:

A platform for cultivation, maintenance, and/or analysis of one or more bio-objects includes one or more integrated bio-object microfluidics modules. Each integrated bio-object microfluidics module is configured to cultivate, maintain, analyze and/or mimic functionalities of a respective bio-object, and includes one or more on-chip pumps; a plurality of fluidic switches; and a microfluidic chip in fluid communication with the one or more on-chip pumps and the plurality of fluidic switches, having at least one chamber for accommodating the bio-object and a plurality of fluidic paths connecting the at least one chamber, the one or more on-chip pumps and the plurality of fluidic switches, and a power and control unit adapted for selectively and individually controlling the one or more on-chip pumps and the plurality of fluidic switches for performing bio-object microfluidics functions.

US Patent:

20140356849, Dec 4, 2014

Filed:

Dec 10, 2012

Appl. No.:

14/363074

Inventors:

- Nashville TN, US
David E. Cliffel - Nashville TN, US
Dmitry A. Markov - Nashville TN, US
John A. McLean - Nashville TN, US
Lisa Joy McCawley - Nashville TN, US
Phillip C. Samson - Nashville TN, US
Ronald S. Reiserer - Nashville TN, US
Frank Emmanuel Block - Nashville TN, US
Jennifer Robin McKenzie - Nashville TN, US

International Classification:

G01N 33/50

US Classification:

435 12, 4352841

Abstract:

In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.

Address:

11440 Willows Grn Way, Glen Allen, VA 23059

VIN:

3GNDA33P07S603260

Make:

CHEVROLET

Model:

HHR 2WD 4DR LT

Year:

2007