Gary Michael Lazar

US Patent:

20130041443, Feb 14, 2013

Filed:

Sep 28, 2012

Appl. No.:

13/631618

Inventors:

Alfred E. Mann Institute for Biomedical Engineerin - Los Angeles CA, US
Gary Steven Lazar - Encino CA, US
Doug Yin - Valencia CA, US

Assignee:

Alfred E. Mann Institute for Biomedical Engineering at the Univ. of Southern California - Los Angeles CA

International Classification:

A61N 1/05

US Classification:

607115

Abstract:

This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion.

US Patent:

20190077852, Mar 14, 2019

Filed:

Feb 28, 2018

Appl. No.:

15/908269

Inventors:

- Oakland CA, US
- Encino CA, US
Lynn K. GORDON - Tarzana CA, US
Gary S. LAZAR - Encino CA, US

International Classification:

C07K 16/18
C07K 16/30
A61K 39/395
G01N 33/574
C07K 16/22
C07K 16/28
A61K 45/06
A61K 47/68
A61K 39/00

Abstract:

Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.

US Patent:

20150329621, Nov 19, 2015

Filed:

Mar 14, 2013

Appl. No.:

14/389098

Inventors:

- Oakland CA, US
- Encino CA, US
Lynn K. GORDON - Tarzana CA, US
Gary S. LAZAR - Encino CA, US

International Classification:

C07K 16/18
A61K 39/395
G01N 33/574
C07K 16/30
C07K 16/22
A61K 47/48
A61K 45/06
C07K 16/28

Abstract:

Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.