George L Dunn

US Patent:

48081515, Feb 28, 1989

Filed:

Apr 27, 1987

Appl. No.:

7/042998

Inventors:

George F. Dunn - Wenonah NJ
Joseph D. Irr - Newark DE
Lise N. Halpern - Newton Highlands MA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

A61M 3700
A61K 3702
A61K 4505

US Classification:

604 6

Abstract:

A lymphocyte-containing white blood cell fraction obtained by standard leukapheresis, elutriation leukapheresis or standard centrifugation can be used for production of lymphokine activated killer cells by incubation with IL-2. Removal of red blood cells and granulocytes by centrifugation on ficoll is not necessary.

US Patent:

41338820, Jan 9, 1979

Filed:

Jun 28, 1976

Appl. No.:

5/700668

Inventors:

George L. Dunn - Wayne PA
John R. E. Hoover - Glenside PA

Assignee:

SmithKline Corporation - Philadelphia PA

International Classification:

A61K 31545
C07D50136

US Classification:

424246

Abstract:

Cephalosporin compounds substituted in the 7-position with a hydroxy-halo substituted. alpha. -aminophenylacetamido group and in the 3-position with a heterocyclicthiomethyl group are prepared by 7-acylation. The products are antibacterial agents.

US Patent:

39622304, Jun 8, 1976

Filed:

Feb 25, 1975

Appl. No.:

5/552916

Inventors:

George L. Dunn - Wayne PA
John R. E. Hoover - Glenside PA

Assignee:

SmithKline & French Laboratories, Inc. - Philadelphia PA

International Classification:

C07D50120

US Classification:

260243C

Abstract:

7-(p-Hydroxymethylphenylglycylamido)cephalosporins are prepared by acylating a 7-aminocephalosporin compound. The products have antibacterial activity.

US Patent:

43082670, Dec 29, 1981

Filed:

Jul 3, 1980

Appl. No.:

6/165822

Inventors:

David A. Berges - Phoenixville PA
George L. Dunn - Wayne PA

Assignee:

SmithKline Corporation - Philadelphia PA

International Classification:

C07D50156
A61K 31545

US Classification:

424246

Abstract:

Novel cephalosporins with improved antibacterial and pharmacokinetic properties are disclosed. These compounds have a 2-alkoxyimino-2-(2-amino-4-thiazolyl)-acetamido group at position 7 and a sulfaminoalkyltetrazolythio group at position 3.

US Patent:

47087102, Nov 24, 1987

Filed:

Mar 27, 1986

Appl. No.:

6/844959

Inventors:

George F. Dunn - Wenonah NJ

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

B01D 2126
B04B 1100

US Classification:

494 37

Abstract:

A process for separating particles from mixtures containing the particles is disclosed. An adoptive transfer therapy process wherein mononuclear cells are separated from a mixture of blood cells by the process is also disclosed. The process comprises supporting the mixture in a centrifuge chamber; subjecting the chamber to a centrifugal force; and forcing a displacing fluid through the chamber, against the centrifugal force, thereby separating the preselected particles from the mixture. The process is further characterized in that the displacing fluid has a density greater than or equal to the density of the preselected particles.

US Patent:

39884511, Oct 26, 1976

Filed:

Oct 20, 1975

Appl. No.:

5/623836

Inventors:

George L. Dunn - Wayne PA

Assignee:

SmithKline Corporation - Philadelphia PA

International Classification:

A61K 3154

US Classification:

424246

Abstract:

7-[. alpha. -Amino-. alpha. -(acylamidophenyl)acetamido]-cephalosporins are prepared. They show improved antibacterial activity especially when they are administered orally.

US Patent:

39311600, Jan 6, 1976

Filed:

May 15, 1974

Appl. No.:

5/470233

Inventors:

George L. Dunn - Wayne PA

Assignee:

SmithKline Corporation - Philadelphia PA

International Classification:

C07D50120

US Classification:

260243C

Abstract:

7-[. alpha. -Amino-. alpha. -(acylamidophenyl)acetamido]-cephalosporins are prepared. They show improved antibacterial activity especially when they are administered orally.

US Patent:

39682269, Jul 6, 1976

Filed:

Sep 30, 1974

Appl. No.:

5/510191

Inventors:

George L. Dunn - Wayne PA
John R. E. Hoover - Glenside PA

Assignee:

SmithKline Corporation - Philadelphia PA

International Classification:

A61K 3154

US Classification:

424246

Abstract:

Cephalosporin compounds substituted at the 7-position with free or substituted. alpha. -aminophenylacetamido and at the 3-position with a heterocyclic thiomethyl group are prepared by displacement of a 3-acetoxymethyl compound with a mercaptoheterocycle. The products are antibacterial agents.