Gregory R Collins

US Patent:

6406631, Jun 18, 2002

Filed:

Oct 30, 2000

Appl. No.:

09/702046

Inventors:

Gregory R. Collins - Monroe NY
Edward C. Spence - Bronx NY
James Summerton - Park Ridge NJ

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6124

US Classification:

210646, 210143, 210252, 2103216, 21032172, 2103232, 2104161, 210645, 210929

Abstract:

In a blood dialysis system including a source of substitution fluid and a blood dialysis machine, a hemodiafiltration system comprises a first dialyzer including a first blood compartment having a first blood inlet which receives blood to be cleaned and a first blood outlet which expels partially diafiltered blood and a first dialysate compartment having a first dialysate inlet and a first dialysate outlet, means for mixing the partially diafiltered blood with substitution fluid from the source to obtain a blood/substitution fluid mixture, and a second dialyzer including a second blood compartment having a second blood inlet which receives the blood/substitution fluid mixture and a second blood outlet which expels diafiltered blood and a second dialysate compartment having a second dialysate inlet and a second dialysate outlet.

US Patent:

6423231, Jul 23, 2002

Filed:

Feb 14, 2000

Appl. No.:

09/485782

Inventors:

Gregory R. Collins - Monroe NY
Edward C. Spence - Bronx NY

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6124

US Classification:

210646, 210 97, 210143, 210252, 2103216, 21032171, 21032172, 2103232, 210434, 210645, 210647, 210929, 604 401, 604 504

Abstract:

A method of hemodiafiltration including the steps of supplying a blood inflow, diafiltering the blood inflow using a first non-isosmotic dialysate fluid to provide a partially diafiltered blood outflow, mixing the partially diafiltered blood outflow with a substitution fluid to provide a blood/substitution fluid mixture, and diafiltering the blood/substitution fluid mixture using a second non-isosmotic dialysate fluid.

US Patent:

6579722, Jun 17, 2003

Filed:

Jul 10, 1995

Appl. No.:

08/500277

Inventors:

Gregory Earl Collins - Waldorf MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

G01N 2176

US Classification:

436172, 436116, 436 68, 422 83, 422 8205, 356 39

Abstract:

A solid phase chemical sensor includes a polymer film which has a chemiluminescent reagent immobilized therein. The polymer film and chemiluminescent reagent are chosen to significantly enhance the selectivity of the sensor to the analyte in the gaseous phase to which the sensor is exposed. The sensor is then positioned so that, when exposed to the gaseous mixture, any chemiluminescence generated will be detected by a photomultiplier tube or other photoelectric device, such as a photodiode. The sensor is particularly useful in the detection of O , N H , SO , NO , and halogenated hydrocarbons.

US Patent:

6635179, Oct 21, 2003

Filed:

Dec 30, 1999

Appl. No.:

09/477081

Inventors:

James Summerton - Park Ridge NJ
Gregory R. Collins - Monroe NY

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6100

US Classification:

210650, 2103218, 21032181, 2103219

Abstract:

A filtration assembly is presented which removes bacteria and endotoxin from a solution so that a sterile fluid is produced. The sterile fluid is suitable for direct on-line infusion to a patient from a device, such as a dialysis machine. The filtration assembly is constructed so that two separate filtration compartments exist, resulting in redundant filtration of the fluid prior to infusion. Each compartment holds a filter which preferably consists of a longitudinal bundle of semipermeable hollow fibers. The filter is sized so that it creates a separate area within the compartment for filtrate and infusate flow. This redundant filtration produces a lower risk of creating a pyrogenic or septic condition in the patient due to filter failure.

US Patent:

6716356, Apr 6, 2004

Filed:

Dec 6, 2001

Appl. No.:

10/009450

Inventors:

Gregory R. Collins - Monroe NY
James Summerton - Park Ridge NJ
Edward Spence - Bronx NY

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6124

US Classification:

210646, 2101952, 2103216, 21032171, 21032172, 2104331, 210434, 210645, 210739, 210805, 210175

Abstract:

The present invention provides a hemodialysis or hemodiafiltration system and method using two dialyzer stages (122, 138), wherein the temperature of a dialysate fluid stream of the first cartridge (122) is increased such that the blood in the first cartridge (122) is dialyzed or diafiltered at an elevated temperature, while blood in the second cartridge (138) is dialyzed or diafiltered against a dialysate stream at normal blood temperature. This results in an increased solute diffusivity and a corresponding increase in removal of blood substances by diffusion. When diafiltration is performed, an additional removal of substances occurs by convection as a larger portion of plasma water from a blood compartment (142) can be filtered across a semi-permeable membrance (140) at the same transmembrane pressure due to the reduced viscosity of the heated blood and plasma water.

US Patent:

6719907, Apr 13, 2004

Filed:

Oct 30, 2001

Appl. No.:

10/021478

Inventors:

Gregory R Collins - Monroe NY
James Summerton - Hillsdale NJ
Edward Spence - Bronx NY

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6100

US Classification:

210646, 2103216, 21032164, 21032172, 2103218, 21032181, 21032188, 21032189, 2103219

Abstract:

A dual-stage filtration cartridge is provided. The cartridge can be embodied as a mid-dilution hemodiafiltration cartridge or a redundant sterilization filtration cartridge. The cartridge includes a housing having a first end and an opposing second end. The housing has a primary fluid inlet and outlet at the first end of the cartridge. The housing also defines first and second filtration stages with the first filtration stage including first filtering elements disposed between the first and second ends of the housing. Each stage has a separate inter-lumen fiber space, but shares a common extra-lumen space. The primary fluid inlet communicates with the first filtering elements at the first end so that fluid flows through the first filtering elements toward the second end. The second filtration stage includes second filtering elements disposed between the first and second ends of the housing with the fluid outlet communicating with the second filtering elements at the first end.

US Patent:

6821431, Nov 23, 2004

Filed:

Jul 9, 2002

Appl. No.:

10/181138

Inventors:

Gregory R. Collins - Monroe NY
James Summerton - Hillsdale NJ
Edward Spence - Bronx NY

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D 6124

US Classification:

210646, 2102572, 2103216, 21032171, 21032172, 2104331, 210645, 210647

Abstract:

A dual-stage system and methods for using the same include first and second filtration cartridges is provided and is particularly suited for hemodiafiltration and/or hemodialysis. As fluid enters the first diafiltration cartridge, the hydrogenion concentration (pH) is reduced by exposing it to an acidic solution such as citric acid across a filter membrane. This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at lower pH. As the filtered fluid enters the second filtration cartridge, the pH of the fluid is restored to normal levels prior to infusion to a patient.

US Patent:

6916424, Jul 12, 2005

Filed:

Feb 7, 2002

Appl. No.:

10/072464

Inventors:

Gregory R Collins - Monroe NY, US
James Summerton - Hillsdale NJ, US
Edward Spence - Bronx NY, US

Assignee:

Nephros, Inc. - New York NY

International Classification:

B01D061/28
B01D061/24
B01D061/32

US Classification:

210646, 210645, 210739, 210929, 210 85, 210 86, 210 87, 210 88, 210 89, 210 90, 210 961, 210 962, 210 97, 210 98, 210103, 210104, 210134, 210136, 210137, 210138, 210143, 210252, 2103216, 21032172, 2103232, 604 401, 604 501

Abstract:

This invention provides a method and apparatus for a hemodiafiltration delivery module that is used in conjunction with a UF controlled dialysis machine to enable hemodiafiltration therapy to be performed. The advantage is that one can fully utilize a current functioning dialysis machine to perform a hemodiafiltration therapy as opposed to purchasing a completely new machine that offers this capability.

Address:

PO Box 181817, Coronado, CA 92178

Phone:

(801)2559299

VIN:

1HGCM56877A143786

Make:

HONDA

Model:

ACCORD

Year:

2007