Han Wen Chang

US Patent:

6965018, Nov 15, 2005

Filed:

Jun 6, 2001

Appl. No.:

09/875338

Inventors:

Glen E Mikesell - Hamilton NJ, US
Han Chang - Princeton Junction NJ, US
Robert J. Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K016/00
C12N005/12
C12P021/08
A61K039/395
G01N033/53

US Classification:

5303881, 5303871, 5303879, 5303882, 53038823, 5303911, 5303913, 5303917, 435326, 435331, 435 7021, 435810, 436512, 436548, 4241331, 4241411, 4241431, 4241441

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

7056737, Jun 6, 2006

Filed:

Feb 13, 2002

Appl. No.:

10/075846

Inventors:

John N. Feder - Belle Mead NJ, US
Liana Lee - North Brunswick NJ, US
Jian Chen - Princeton NJ, US
Nathan O. Siemers - Pennington NJ, US
Han Chang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 5/00

US Classification:

435325, 4353201, 4352523, 435 6, 536 235

Abstract:

The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7101686, Sep 5, 2006

Filed:

Nov 20, 2001

Appl. No.:

09/988971

Inventors:

Han Chang - Princeton Junction NJ, US
Wen-Pin Yang - Princeton NJ, US
Yuli Wu - Newtown PA, US
Gena S. Whitney - Lawrenceville NJ, US
Juan J. Perez-villar - Mercerville NJ, US
Steven B. Kanner - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 21/06
C12N 15/63
C12N 15/00
C07H 21/04

US Classification:

435 691, 435455, 4352523, 4353201, 536 235

Abstract:

The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

US Patent:

7223557, May 29, 2007

Filed:

May 22, 2002

Appl. No.:

10/153244

Inventors:

Ning Lee - Belle Mead NJ, US
Jian Chen - Princeton NJ, US
John N. Feder - Belle Mead NJ, US
Shujian Wu - Langhorne PA, US
Han Chang - Princeton Junction NJ, US
Liana M. Le - San Francisco CA, US
Michael A. Blanar - Malvern PA, US
David Bol - Gaithersburg MD, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12Q 1/68
C07H 21/04
C12P 21/02
C12N 5/06
C07K 14/705

US Classification:

435 691, 435 701, 4352523, 435325, 4353201, 530350, 536 231, 536 235

Abstract:

The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7517957, Apr 14, 2009

Filed:

May 5, 2006

Appl. No.:

11/429515

Inventors:

Han Chang - Princeton Junction NJ, US
Wen-Pin Yang - Princeton NJ, US
Yuli Wu - Newtown PA, US
Gena S. Whitney - Lawrenceville NJ, US
Juan J. Perez-villar - Mercerville NJ, US
Steven B. Kanner - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/00

US Classification:

530350

Abstract:

The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

US Patent:

7541434, Jun 2, 2009

Filed:

Mar 21, 2007

Appl. No.:

11/726234

Inventors:

Ning Lee - Belle Mead NJ, US
Jian Chen - Princeton NJ, US
Shujian Wu - Langhorne PA, US
Han Chang - Princeton Junction NJ, US
Michael A. Blanar - Malvern PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/47
C12N 15/07
C12N 15/64
C12P 21/02

US Classification:

530350, 435 691, 4353201, 435325, 435471

Abstract:

The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7667003, Feb 23, 2010

Filed:

Sep 4, 2008

Appl. No.:

12/231623

Inventors:

Juan J. Perez-Villar - Valencia, ES
Han Chang - Princeton Junction NJ, US
Steven B. Kanner - Santa Monica CA, US
Gena S. Whitney - Lawrenceville NJ, US
Yuli Wu - Newtown PA, US
Wen-Pin Yang - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 16/28

US Classification:

5303879, 5303881, 53038815, 435810

Abstract:

The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

US Patent:

20030032776, Feb 13, 2003

Filed:

Nov 1, 2001

Appl. No.:

10/040805

Inventors:

John Feder - Belle Mead NJ, US
Liana Lee - North Brunswick NJ, US
Jian Chen - Princeton NJ, US
Donald Jackson - Lawrenceville NJ, US
Chandra Ramanathan - Wallingford CT, US
Nathan Siemers - Pennington NJ, US
Han Chang - Princeton Junction NJ, US

International Classification:

C07K014/435
C07H021/04
C12P021/02
C12N005/06

US Classification:

530/350000, 536/023500, 435/069100, 435/325000, 435/320100

Abstract:

The present invention provides novel polynucleotides encoding K+Mbeta1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+Mbeta1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.