Hee Jea Cho

US Patent:

20090291068, Nov 26, 2009

Filed:

Feb 2, 2007

Appl. No.:

11/701985

Inventors:

Eduardo Marban - Beverly Hills CA, US
Ronald A. Li - Baltimore MD, US
Suk-Ying Tsang - Shatin, HK
Hee Cheol Cho - Columbia MD, US
Tian Xue - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 35/12
C12N 5/06
A61K 48/00

US Classification:

424 9321, 435455, 514 44 R

Abstract:

The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).

US Patent:

20210260158, Aug 26, 2021

Filed:

Mar 8, 2021

Appl. No.:

17/194543

Inventors:

- Los Angeles CA, US
Hee Cheol Cho - Los Angeles CA, US

Assignee:

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

International Classification:

A61K 38/17
C12N 5/077
C07K 14/47
A61K 35/34

Abstract:

Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.

US Patent:

20180071364, Mar 15, 2018

Filed:

Aug 16, 2017

Appl. No.:

15/678973

Inventors:

- Los Angeles CA, US
Hee Cheol Cho - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 38/17
A61K 35/34
C07K 14/47
C12N 5/077

Abstract:

Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.

US Patent:

20150359845, Dec 17, 2015

Filed:

Nov 8, 2012

Appl. No.:

14/357195

Inventors:

- Los Angeles CA, US
Hee Cheol Cho - Los Angeles CA, US

Assignee:

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

International Classification:

A61K 38/17
A61K 35/34

Abstract:

Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.