Jacqueline Marie Morris

US Patent:

20170029461, Feb 2, 2017

Filed:

Jan 20, 2015

Appl. No.:

15/112984

Inventors:

- Little Rock AR, US
Srinivas Jayanthi - Fayetteville AR, US
Jacqueline Morris - Fayetteville AR, US
Alicia Brown - Springdale AR, US
David McNabb - Fayetteville AR, US
Ralph Henry - Fayetteville AR, US

International Classification:

C07K 1/22
C12N 9/64
B01D 15/38
B01J 20/28
B01D 69/08
B01D 15/22
B01J 20/286
C07K 14/00
B01D 15/20

Abstract:

In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.

US Patent:

20160145597, May 26, 2016

Filed:

Jan 21, 2014

Appl. No.:

14/378230

Inventors:

- Little Rock AR, US
Srinivas Jayanthi - Fayetteville AR, US
Jacqueline Morris - Fayetteville AR, US
Alicia Brown - Springdale AR, US
David McNabb - Fayetteville AR, US
Ralph Henry - Fayetteville AR, US

International Classification:

C12N 9/64
C07K 14/00

Abstract:

In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.