James S Mcclintock

US Patent:

7625885, Dec 1, 2009

Filed:

Feb 17, 2005

Appl. No.:

10/906386

Inventors:

Bill J Baker - Tampa FL, US
James B McClintock - Birmingham AL, US
Charles D Amsler - Pelham AL, US

Assignee:

University of South Florida - Tampa FL
The UAB Research Foundation - Birmingham AL

International Classification:

A61K 31/585
A61K 31/665

US Classification:

514175, 514 99

Abstract:

A compound or groups of compounds, present in an active principle, derived from tunicates of the species , as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

US Patent:

20090192215, Jul 30, 2009

Filed:

Sep 18, 2006

Appl. No.:

12/066938

Inventors:

Bill Baker - Tampa FL, US
Thushara Diyabalanage - Tampa FL, US
James B. McClintock - Birmingham AL, US
Charles D. Amsler - Pelham AL, US

Assignee:

University of South Florida - Tampa FL
UAB Research Foundation - Birmingham AL

International Classification:

A61K 31/335
C07D 313/00
C12N 9/99
A61P 35/00

US Classification:

514450, 549271, 435184

Abstract:

The present invention concerns groups of compounds derived from tunicates of the species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.

US Patent:

20100063137, Mar 11, 2010

Filed:

Nov 13, 2009

Appl. No.:

12/618461

Inventors:

Bill J. Baker - Tampa FL, US
Thushara Diyabalanage - Tampa FL, US
James B. McClintock - Birmingham AL, US
Charles D. Amsler - Pelham AL, US

Assignee:

University of South Florida - Tampa FL
The UAB Research Foundation - Birmingham AL

International Classification:

A61K 31/365
C07D 313/00
A61P 35/00

US Classification:

514450, 549271

Abstract:

The present invention concerns compounds derived from tunicates of the species , as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.