James M Summers

US Patent:

54865255, Jan 23, 1996

Filed:

Dec 5, 1994

Appl. No.:

8/347528

Inventors:

James B. Summers - Libertyville IL
Steven K. Davidsen - Libertyville IL
Michael L. Curtin - Lindenhurst IL
H. Robin Heyman - Chicago IL
George S. Sheppard - Wilmette IL
Lianhong Xu - Libertyville IL
George M. Carrera - Des Plaines IL
Robert B. Garland - Northbrook IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31435
C07D47104

US Classification:

514303

Abstract:

The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

US Patent:

52505650, Oct 5, 1993

Filed:

Jan 21, 1992

Appl. No.:

7/823411

Inventors:

Dee W. Brooks - Libertyville IL
James B. Summers - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3138
A61K 3134
C07D20904
C07D33352

US Classification:

514443

Abstract:

Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula ##STR1## in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic aryl. R. sup. 1 is an alkyl, alkenyl, amino, alkylamino, dialkylamino, or hydroxyamino group or an amine group bearing a metabolically cleavable leaving group. M is hydrogen, a pharmaceutically acceptable cation or a metabolically cleavable leaving group, with the proviso that either M or R. sup. 1 must bear a metabolically cleavable leaving group.

US Patent:

49924648, Feb 12, 1991

Filed:

Nov 1, 1989

Appl. No.:

7/430710

Inventors:

Dee W. Brooks - Libertyville IL
James B. Summers - Libertyville IL
Karen E. Rodriques - Grayslake IL
Robert G. Maki - Kenosha WI
Joseph F. Dellaria - Lindenhurst IL
James H. Holms - Gurnee IL
Jimmie L. Moore - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3138
C07D33356

US Classification:

514443

Abstract:

Compounds, compositions a method of inhibiting lipoxygenase and treating related disorders are disclosed. The compounds are of the formula: Ar-A(R. sub. 2). sub. n -N(OM)-CZ-R. sub. 1 wherein Ar is ##STR1## where X is O, S, SO. sub. 2 or NR. sub. 3 ; R. sub. 3 is hydrogen, alkyl, alkylaryl, alkoyl, alkylakoyl, aroyl or alkylaroyl; Y is hydrogen, halogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, --OR, --SR, --COOR, --COR, --CON(R). sub. 2, --OCOR, --N(R). sub. 2, --O(CH). sub. 2, --SO. sub. 2 R, --SO. sub. 2 N(R). sub. 2, --O(CH. sub. 2). sub. p OR, --CN, --NO. sub. 2, --O(CH). sub. p O(CH. sub. 2). sub. p OR or --CF. sub. 3 ; R is hydrogen, hydroxyl, alkyl, alkylaryl or aryl; m is 0 to 5; p is 1 to 4; A is C. sub. 1 -C. sub. 12 alkylene or C. sub. 2 -C. sub. 14 alkenylene; R. sub.

US Patent:

52200590, Jun 15, 1993

Filed:

Apr 19, 1990

Appl. No.:

7/511380

Inventors:

Dee W. Brooks - Libertyville IL
Joseph F. Dellaria - Lindenhurst IL
James B. Summers - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 8308
C07D 8310
A61K 31325

US Classification:

562623

Abstract:

Compounds of the formula: ##STR1## wherein R. sub. 1 is selected from (1) hydrogen; (2) --NR. sub. 2 R. sub. 3, --OR. sub. 2 or --SR. sub. 2 where R. sub. 2 and R. sub. 3 are independently selected from hydrogen, alkyl, aryl and alkylaryl; and (3) optionally substituted C1-C8 alkyl, C2-C8 alkenyl, arylalkyl or cycloalkyl; Y is selected from sulfur and oxygen; n is an integer selected from 0 and 1; M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group; and Z is a residue of a non-steroidal antiinflammatory drug of general form Z--COOH; or a pharmaceutically acceptable salt, ester or prodrug thereof, as well as pharmaceutical compositions containing the above compounds and a method for their use as lipoxygenase inhibitors.

US Patent:

46056696, Aug 12, 1986

Filed:

Apr 26, 1985

Appl. No.:

6/727464

Inventors:

James B. Summers - Libertyville IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 31185
A61K 31205
C07C 8310

US Classification:

514575

Abstract:

Compounds of the formula ##STR1## where R. sub. 1 is H, or C. sub. 1 to C. sub. 6 alkyl; R. sub. 2 is selected from C. sub. 1 to C. sub. 22 alkyl, cycloalkyl, aralky or alkenyl; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12- and 15-lipoxygenase.

US Patent:

51751836, Dec 29, 1992

Filed:

Jul 10, 1991

Appl. No.:

7/721530

Inventors:

Dee W. Brooks - Libertyville IL
James B. Summers - Libertyville IL
Karen E. Rodriques - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3138
C07D33332
C07D33322

US Classification:

514438

Abstract:

Certain N-aryl, N-heteroaryl-, N-arylalkyl-, N-heteroarylalkyl-, N-arylcyclopropyl- and N-heteroaryl-cyclopropyl-N'-hydroxyurea compounds are inhibitors of lipoxygenase enzyme activity and are thus useful agents in treating disease states such as asthma, arthritis, allergy, psoriasis, inflammatory bowel disease, gout, adult respiratory distress syndrome, endotoxin shock, and other inflammatory conditions in which the products of the arachidonic acid cascade are implicated.

US Patent:

59523204, Sep 14, 1999

Filed:

Dec 17, 1997

Appl. No.:

8/992668

Inventors:

Steven K. Davidsen - Libertyville IL
Douglas H. Steinman - Morton Grove IL
George S. Sheppard - Wilmette IL
Lianhong Xu - Libertyville IL
James H. Holms - Gurnee IL
Yan Guo - Gurnee IL
James B. Summers - Libertyville IL
Alan S. Florjancic - Lake Bluff IL
Michael R. Michaelides - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3133
C07D22504
C07D26722
C07D28118

US Classification:

514183

Abstract:

Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.

US Patent:

51128489, May 12, 1992

Filed:

Apr 19, 1990

Appl. No.:

7/487982

Inventors:

Dee W. Brooks - Libertyville IL
Bruce P. Gunn - Saraland AL
James H. Holms - Gurnee IL
James B. Summers - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140
C07D30702
C07D20700

US Classification:

514424

Abstract:

Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.