Janet Lee Plummer

US Patent:

62916785, Sep 18, 2001

Filed:

Dec 11, 1998

Appl. No.:

9/202377

Inventors:

Kent A. Berryman - Ann Arbor MI
Annette M. Doherty - Ann Arbor MI
Jeremy J. Edmunds - Ypsilanti MI
Janet S. Plummer - Dexter MI

Assignee:

Warner-Lambert Company - Ann Arbor MI

International Classification:

C07D27728

US Classification:

546209

Abstract:

A process for the preparation of novel keto heterocycle derivatives of basic natural and unnatural amino acids which affords products of high enantiomeric excess where a metalated heterocycle is reacted with N,O-dialkyl amide of an amino acid containing arylsulphonamide protected side chain amine in high chemical and optical yield as well as the novel compounds obtained by the process.

US Patent:

54895987, Feb 6, 1996

Filed:

Jun 8, 1994

Appl. No.:

8/255597

Inventors:

David T. Connor - Ann Arbor MI
Janet S. Plummer - Dexter MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3141

US Classification:

514384

Abstract:

5-Aryltriazol-3-thiones are useful for inhibiting adhesion of Mac-1 and thereby providing cytoprotection for diseases mediated by Mac-1 adhesion.