Janice K Bell

US Patent:

8476320, Jul 2, 2013

Filed:

Jan 16, 2008

Appl. No.:

12/523305

Inventors:

Manoj Maniar - Fremont CA, US
Janice W Bell - Narberth PA, US

Assignee:

Onconova Therapeutics, Inc - Newtown PA

International Classification:

A61K 31/10

US Classification:

514710

Abstract:

Formulations are provided for parenteral administration of (amino substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones and the sodium and potassium salts thereof for the prevention and/or treatment of conditions mediated by abnormal cell proliferation. Composition for parenteral administration are provided which comprise an effective amount of a compound of formula I.

US Patent:

20110028504, Feb 3, 2011

Filed:

Jul 28, 2006

Appl. No.:

11/989468

Inventors:

Manoj Maniar - Fremont CA, US
Stanley C. Bell - Narberth PA, US
Janice W. Bell - Narberth PA, US

Assignee:

ONCONOVA THERAPEUTICS, INC. - Newtown PA

International Classification:

A61K 31/44
A61K 31/192
A61K 31/10
A61K 31/277
A61K 31/341
A61P 43/00

US Classification:

514277, 514568, 514710, 514520, 514461

Abstract:

A pharmaceutical composition is provided for administration prior to or after exposure to ionizing radiation for reducing toxic effects of the radiation in a subject. An effective amount of the pharmaceutical composition provided comprising an effective amount of at least one radioprotective α, β unsaturated aryl sulfone, and at least one component selected from the group consisting of a) at least one water soluble polymer in an amount between about 0.5% and about 90% w/v, b) at least one chemically modified cyclodextrin in an amount between about 20% and about 60% w/v, and c) DMA in an amount between about 10% and about 50% w/v.