Jena J. Steinle - Olive Branch MS, US Kimberly P. Williams - Memphis TN, US Jayaprakash Pagadala - Memphis TN, US Duane D. Miller - Germantown TN, US
Assignee:
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION - Knoxville TN
International Classification:
A61K 31/137 C07C 215/56 C12N 5/071 A61P 27/02
US Classification:
514653, 564361, 435375
Abstract:
Provided herein are methods for improving function in a retinal cell associated with a diabetic condition and for treating a diabetic retinopathic condition in a subject. The methods comprise contacting the retinal cell or administering to the subject a beta-adrenergic receptor agonist or R-isomer thereof such as have the chemical structural formula:where Ris (CH)(CH)orwhere n is 1 to 4, Ris H or H.HX, where X is a halide and Ris O(CH)CHat one or more of C2-C6, where m is 0 to 4. Also provided are BAR agonists having the structural where Ris the (CH)-phenyl-Rsubstituent and the hydroxy-benzene moiety is 1,2-benzene diol or 1,3-benzene diol.