Jennifer Anne Caldwell

US Patent:

20100145223, Jun 10, 2010

Filed:

Nov 12, 2009

Appl. No.:

12/617256

Inventors:

Eric A. Postel - Durham NC, US
R. Keith Shuler - Durham NC, US
Jennifer Vaughn Caldwell - Durham NC, US
Michael Hauser - Durham NC, US
Silke Schmidt - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61B 3/14
A61F 9/00
A61B 3/10

US Classification:

600558, 351206

Abstract:

Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.

US Patent:

20110183340, Jul 28, 2011

Filed:

Feb 28, 2011

Appl. No.:

13/036780

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 612, 435 61, 435 71, 435 792

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.

US Patent:

20090263801, Oct 22, 2009

Filed:

Jan 2, 2009

Appl. No.:

12/348167

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C12Q 1/68
G01N 33/535
C12Q 1/02

US Classification:

435 6, 435 792, 435 29

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.