Jennifer K Meyers

US Patent:

20050261224, Nov 24, 2005

Filed:

Mar 14, 2005

Appl. No.:

11/080091

Inventors:

Vijay Kuchroo - Newton MA, US
Sumone Chakravarti - Oakland CA, US
Terry Strom - Brookline MA, US
Xin Zheng - Wellesley MA, US
Jennifer Meyers - Brighton MA, US

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

A61K048/00

US Classification:

514044000

Abstract:

The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.

US Patent:

20110045002, Feb 24, 2011

Filed:

Apr 26, 2010

Appl. No.:

12/767434

Inventors:

Vijay K. Kuchroo - Newton MA, US
Sumone Chakravarti - Victoria, AU
Terry Strom - Brookline MA, US
Xin Xiao Zheng - Pittsburgh PA, US
Jennifer Hartt Meyers - Rockville MD, US

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

A61K 39/395
A61K 38/02
A61P 3/10
A61P 29/00
A61P 37/06
A61P 17/00
A61K 38/38

US Classification:

4241721, 514 11, 514 73, 514 166, 514 179, 514 187, 514 152

Abstract:

The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.

US Patent:

20130195895, Aug 1, 2013

Filed:

Jan 25, 2013

Appl. No.:

13/750092

Inventors:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA, US
Terry Strom - Brookline MA, US
Xin Xiao Zheng - Pittsburgh PA, US
Jennifer Meyers - Rockville MD, US

Assignee:

BETH ISRAEL DEACONESS MEDICAL CENTER, INC. - Boston MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

A61K 39/395
A61K 38/17

US Classification:

4241721, 4242781, 4241301

Abstract:

The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.

US Patent:

20150079085, Mar 19, 2015

Filed:

Oct 1, 2014

Appl. No.:

14/503768

Inventors:

- Boston MA, US
Terry Strom - Brookline MA, US
Xin Xiao Zheng - Pittsburgh PA, US
Jennifer Meyers - Rockville MD, US

International Classification:

C07K 16/28
C07K 14/705

US Classification:

4241341

Abstract:

The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.