Disclosed are methods and compositions for the treatment of a variety of illnesses by mimicking the outer leaflet of an apotic cell to allow for the induction of macrophage phagocytosis to serve as a means of removing unwanted and diseased cells using phosphatidylserine/cell-surface recognition domain conjugate compositions. Also disclosed are methods for making phosphatidylserine/cell-surface recognition domain conjugate compositions and their formulation for use in a various pharmaceutical applications including the treatment of diverse cancers and other maladies.
Ajit Varki - Del Mar CA, US Jennifer Stevenson - San Diego CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 31/727 G01N 33/567
US Classification:
514056000, 435007200
Abstract:
The disclosure provides in vitro and in vivo methods for identifying Heparins and Heparinoids that modulate the activity of selecting. The disclosure also provides Heparins and Heparinoids that modulate the activity of selecting. The identification and isolation of these heparin formulations has the potential to mediate a wide variety of pathologies mediated by P- and/or L-selectin, including hematogenous metastasis, diseases associated with inflammation (e.g., asthma, arthritis, allergic dermatitis), ischemia-reperfusion injury, or other pathologies such as sickle cell anemia. Selectin inhibition can be achieved at plasma concentrations lower than those that cause excessive anticoagulation or unwanted bleeding in a human subject.
Ajit Varki - Del Mar CA, US Jennifer L. Stevenson - Santa Clarita CA, US
International Classification:
A61K 31/727 C12Q 1/48
US Classification:
514 56, 435 15
Abstract:
The disclosure provides in vitro and in vivo methods for identifying Heparins and Heparinoids that modulate the activity of selectins. The disclosure also provides Heparins and Heparinoids that modulate the activity of selectins. The identification and isolation of these heparin formulations has the potential to mediate a wide variety of pathologies mediated by P- and/or L-selectin, including hematogenous metastasis, diseases associated with inflammation (e.g., asthma, arthritis, allergic dermatitis), ischemia-reperfusion injury, or other pathologies such as sickle cell anemia. Selectin inhibition can be achieved at plasma concentrations lower than those that cause excessive anticoagulation or unwanted bleeding in a human subject.
ARCT Architecture - New York, New York since Jun 2012
Architecture Associate
City College of New York Aug 2011 - May 2013
City College Survey of Architecture History Teaching Assistant
Graphic Design Freelancer - New York, New York Jun 2011 - Jun 2012
Graphic Designer
Student Center Jun 2007 - Jun 2010
University of Kentucky
Education:
City University of New York City College 2010 - 2013
Master of Architecture (M.Arch.)
University of Kentucky 2006 - 2010
BA Architecture
Skills:
Rhino Adobe Creative Suite AutoCAD Vray Revit SketchUp Specifications Ecotect Model Making Microsoft Office Rhino 3D
Research Assistant - SWAN at University of Pittsburgh
Location:
Pittsburgh, Pennsylvania
Industry:
Higher Education
Work:
University of Pittsburgh - Graduate School of Public Health Department of Epidemiology since May 2012
Research Assistant - SWAN
University of Pittsburgh - LRDC Apr 2011 - May 2012
Data Coordinator
West Penn Allegheny Health System May 2009 - Apr 2011
Medical Library Volunteer
Dickie, McCamey & Chilcote Aug 2005 - Apr 2011
Paralegal
University of Pittsburgh Mar 2003 - Aug 2005
Student Worker
Education:
University of Pittsburgh 2007 - 2009
MLIS, Library Science
University of North Carolina at Chapel Hill 2008 - 2008
University of Pittsburgh 2000 - 2005
BS, Psychology
University of Pittsburgh 2012
Post Bac, General Studies
Gerdau since Feb 2009
Human Resources Manager
Gerdau Oct 2008 - Jan 2009
Global Template Team Member
Gerdau Ameristeel Oct 2006 - Oct 2008
Regional HR Manager
Gerdau Ameristeel Nov 2003 - Oct 2006
HR Spcecialist/HR Representative
Schneider Electric/Square D 2000 - 2003
Human Resources Representative
Education:
University of South Carolina-Columbia
Bachelor of Arts, Sociology
Emergency Nursing Portland, OR Jun 2012 to Oct 2012 Staff Nurse, RN, MSN, Good SamaritanPsychiatric Nursing Sausalito, CA May 2011 to Oct 2011 Staff Nurse, RN, MSN, New Dawn Recovery for Eating Disorders PHPEmergency Nursing Oakland, CA Jul 2005 to Sep 2009 Full-Time Registered Nurse II- Per diem RN IIMiramonte High School Orinda, CA 1998 to 2004 English TeacherPre-College Academy
Jun 2003 to Aug 2003 College Writing InstructorMartinez Junior High School Martinez, CA 1995 to 1998 English teacher
Education:
University of California San Francisco, CA 2004 to 2005 Registered Nurse Licensing in NursingUniversity of California San Francisco, CA 2005 Registered Nurse in NursingUniversity of San Francisco 1995 Teaching CredentialUniversity of California, Berkeley Berkeley, CA 1992 Bachelor of Arts in English
An unprecedented number of otherwise healthy adults and children are coming into the emergency room at Henry Ford Medical Center Fairlane in Dearborn, Michigan, sick with strep, said Dr. Jennifer Stevenson, the head of the emergency department.
Attorney Mike Haglund, Jennifer Stevenson, president of the Newport Fishermen's Wives, and Ginny Goblirsch, left, were featured speakers during Tuesday's press conference at the Newport City Hall regarding the U.S. Coast Guard's decision to close the Newport Air Facility. Haglund filed a federal law
Date: Nov 26, 2014
Category: Health
Source: Google
Asian LNG Exports Drive Canadian Gas Industry Purchases
thAmericas eastern markets and gas prices are languishing near a10-year low. To get the gas flowing to Asia, there will need tobe more company takeovers and land acquisitions in Canada likethe Petronas-Progress deal, said Jennifer Stevenson, a Calgary-based fund manager at Dynamic Funds.