Jerald D Lee

US Patent:

6852986, Feb 8, 2005

Filed:

Nov 9, 2000

Appl. No.:

10/111114

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - Newark DE, US

Assignee:

E. I. Du Pont De Nemours and Company - Wilmington DE

International Classification:

G01J001/58

US Classification:

2504581, 2504831, 2504621, 2504591, 2504612

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present flourometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The flourometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each flourescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

7109495, Sep 19, 2006

Filed:

Jun 8, 2004

Appl. No.:

10/863535

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - Newark DE, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

G21K 5/00

US Classification:

2504581, 2504591, 2504612

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

7968856, Jun 28, 2011

Filed:

May 6, 2009

Appl. No.:

12/387759

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - Newark DE, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

G01N 21/64

US Classification:

2504581

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

20070194246, Aug 23, 2007

Filed:

Aug 7, 2006

Appl. No.:

11/462940

Inventors:

Jerald Lee - Mendenhall PA, US
Stanley Dabell - Newark DE, US

International Classification:

G01N 21/64

US Classification:

250458100

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

20080212090, Sep 4, 2008

Filed:

Mar 20, 2008

Appl. No.:

12/052212

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - NewArk DE, US

International Classification:

G01J 3/30

US Classification:

356317

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

20110207142, Aug 25, 2011

Filed:

May 6, 2011

Appl. No.:

13/102634

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - Newark DE, US

International Classification:

C12Q 1/68
G01N 21/64
C12M 1/34

US Classification:

435 612, 2504581, 4352872, 250216

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

20120183968, Jul 19, 2012

Filed:

Jan 17, 2012

Appl. No.:

13/351885

Inventors:

Jerald D. Lee - Mendenhall PA, US
Stanley D. Dabell - Newark DE, US

International Classification:

G01N 21/64
C12M 1/40

US Classification:

435 612, 4352872

Abstract:

This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its to correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled.

US Patent:

44498217, May 22, 1984

Filed:

Jul 14, 1982

Appl. No.:

6/398385

Inventors:

Jerald D. Lee - Mendenhall PA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

G01J 342

US Classification:

356319

Abstract:

A colorimeter for measuring color of an object, in particular for measuring the color of liquids such as paints in a process stream. In the colorimeter, a single analytical light beam, with its blue and red intensity ratio controlled through a feedback loop, is directed to a sample whose color is being measured. A portion of the analytical light beam is reflected from the sample into a grating monochromator which disperses the light beam into its spectra. A detector array is attached to the monochromator which converts the spectra of the light beam into discrete signals which are then multiplexed with instrument status and reference color signals into an A/D converter. The output of the A/D converter is then fed directly to a computer programmed to directly provide standard color values.