Jerome A Fischer

US Patent:

7513093, Apr 7, 2009

Filed:

Dec 13, 2005

Appl. No.:

11/301365

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome A. Fischer - Warren NJ, US
Stephen Rothenburger - Neshanic Station NJ, US
Robert Cerwin - Pipersville PA, US
James R. McDivitt - Flemington NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

B65B 11/58
B65B 55/00

US Classification:

53449, 53425, 53167

Abstract:

A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

US Patent:

8133437, Mar 13, 2012

Filed:

Dec 13, 2005

Appl. No.:

11/301364

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome A. Fischer - Warren NJ, US
Stephen Rothenburger - Neshanic Station NJ, US
Robert Cerwin - Pipersville PA, US
James R. McDivitt - Flemington NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

A61L 9/00
A61L 2/00
A61L 2/18
A61L 2/20
B01J 7/00
B65B 11/58
A61B 17/06
A61L 17/00

US Classification:

422 29, 422 28, 422 33, 422292, 422294, 422305, 53449, 206 633, 606228

Abstract:

A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device. Alternatively, the packaged medical device is produced according to the steps of positioning a medical device within a package; exposing the package having the medical device to an antimicrobial agent source; and subjecting the package having the medical device and the antimicrobial agent source to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device within the package, thereby substantially inhibiting bacterial colonization on the medical device.

US Patent:

8156718, Apr 17, 2012

Filed:

Apr 2, 2009

Appl. No.:

12/417518

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome A. Fischer - Warren NJ, US
Stephen Rothenburger - Neshanic Station NJ, US
Robert Cerwin - Pipersville PA, US
James R. McDivitt - Flemington NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

B65B 55/02

US Classification:

53425, 53449, 206 633, 606228

Abstract:

A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

US Patent:

20040068293, Apr 8, 2004

Filed:

Feb 15, 2003

Appl. No.:

10/367497

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome Fischer - Warren NJ, US
James McDivitt - Flemington NJ, US
Stephen Rothenburger - Phillipsburg NJ, US
Robert Cerwin - Pipersville PA, US

International Classification:

A61B017/04

US Classification:

606/228000

Abstract:

An antimicrobial suture assembly comprising a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture; and a method for making.

US Patent:

20040068294, Apr 8, 2004

Filed:

Feb 15, 2003

Appl. No.:

10/367565

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome Fischer - Warren NJ, US

International Classification:

A61B017/04

US Classification:

606/228000

Abstract:

A braided suture having antimicrobial properties comprising an elongate braided structure formed from a plurality of polymeric filaments, said filaments being formed from a polymeric material that is absorbable under physiological conditions; and a coating material disposed on said elongate braided structure, said coating comprising a film forming absorbable polymer, a substantially water-insoluble salt of a fatty acid and an effective amount of an antimicrobial agent selected from the group consisting of halogenated hydroxyl ethers, halogen-o-hydroxydiphenyl ethers, acyloxydiphenyl ethers and combinations thereof, said effective amount being sufficient to substantially inhibit microbial growth on or adjacent said suture when said suture is implanted in a patient's body.

US Patent:

20040220614, Nov 4, 2004

Filed:

Mar 25, 2004

Appl. No.:

10/808669

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome Fischer - Warren NJ, US
Stephen Rothenburger - Phillipsburg NJ, US

International Classification:

A61B017/04

US Classification:

606/228000

Abstract:

An antimicrobial suture assembly comprising a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, and at least one active agent selected from the group consisting of a biocide, a disinfectant, an antiseptic, an antibiotic, an antimicrobial peptide, a lytic bacteriophage, a surfactant; an adhesion blocker; an oligonucleotide, an efflux pump inhibitors; a photosensitive dye, an immune modulator and a chelator.

US Patent:

20050101993, May 12, 2005

Filed:

Jun 25, 2003

Appl. No.:

10/603317

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome Fischer - Warren NJ, US
Robert Cerwin - Pipersville PA, US

International Classification:

A61B017/04

US Classification:

606228000

Abstract:

A packaged medical device produced according to the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device. Alternatively, the packaged medical device is produced according to the steps of positioning a medical device within a package; exposing the package having the medical device to an antimicrobial agent source; and subjecting the package having the medical device and the antimicrobial agent source to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device within the package, thereby substantially inhibiting bacterial colonization on the medical device.

US Patent:

20120199502, Aug 9, 2012

Filed:

Apr 17, 2012

Appl. No.:

13/449184

Inventors:

Howard Scalzo - Kenilworth NJ, US
Jerome A. Fischer - Warren NJ, US
Stephen Rothenburger - Neshanic Station NJ, US
Robert Cerwin - Pipersville PA, US
James R. McDivitt - Flemington NJ, US

Assignee:

ETHICON, INC. - Somerville NJ

International Classification:

A61B 17/06
B65B 55/02

US Classification:

206 633, 53425

Abstract:

A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.