Jerry Shunneng Sun

US Patent:

6482943, Nov 19, 2002

Filed:

Apr 27, 2000

Appl. No.:

09/562980

Inventors:

Andrei V. Blokhin - Madison WI
Benjamin Frydman - Madison WI
Laurence J. Marton - Madison WI
Karen M. Neder - Madison WI
Jerry Shunneng Sun - Madison WI

Assignee:

SLIL Biomedical Corporation - Madison WI

International Classification:

C07B 4700

US Classification:

540145

Abstract:

Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

US Patent:

6809176, Oct 26, 2004

Filed:

May 6, 2002

Appl. No.:

10/139978

Inventors:

Andrei V. Blokhin - Madison WI
Benjamin Frydman - Madison WI
Laurence J. Marton - Madison WI
Karen M. Neder - Madison WI
Jerry Shunneng Sun - Madison WI

Assignee:

SLIL Biomedical, Corporation - Madison WI

International Classification:

C07K 200

US Classification:

530300, 549389, 549391, 549458, 549461, 552292

Abstract:

Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

US Patent:

7253207, Aug 7, 2007

Filed:

Aug 2, 2004

Appl. No.:

10/909978

Inventors:

Andrei V. Blokhin - Madison WI, US
Benjamin Frydman - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Karen M. Neder - Madison WI, US
Jerry Shunneng Sun - Madison WI, US

Assignee:

Cellgate, Inc. - Redwood City CA

International Classification:

A61K 31/35
C07D 311/92

US Classification:

514454, 514455, 530300, 549389, 549458, 552290, 552291, 552292, 552293

Abstract:

Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

US Patent:

7612210, Nov 3, 2009

Filed:

Dec 4, 2006

Appl. No.:

11/633207

Inventors:

Paige Erin Mahaney - Pottstown PA, US
Madelene Miyoko Antane - West Windsor NJ, US
Jerry Shunneng Sun - Blauvelt NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 263/04

US Classification:

548230, 548215, 548225, 548229

Abstract:

A process for the enantioselective synthesis of an (S)- or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described. The method involves the steps of (a) reacting an (S) or (R) 4-benzyloxazolidinone with a mixed anhydride of a methyoxyphenylacetic acid under conditions which form a oxazolidinone, (4S)- or (4R)-4-benzyl-3-[methyoxyphenyl]acetyl]-oxazolidin-2-one, (b) treating the (4S)- or (4R)-4-benzyl-3-[(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one with an aprotic amine base and titanium chloride in a chlorinated solvent under conditions which permit formation of the corresponding anion, (c) mixing the corresponding anion with titanium chloride and cylcohexanone under conditions which permit an aldol reaction to form the corresponding (4S)- or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one,(d) hydrolyzing the (4S)— or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one to form a chiral acid (2S or 2R)-(1-hydroxycyclohexyl)-methoxyphenyl)acetic acid, (e) coupling the chiral phenylacid to a secondary amine to form an amide, and (f) reducing the amide to form an (S) or (R) 1[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol or a salt thereof.

US Patent:

7781427, Aug 24, 2010

Filed:

Nov 4, 2005

Appl. No.:

11/267448

Inventors:

Christoph Dehnhardt - New York NY, US
Sreenivasulu Megati - New City NY, US
Jerry Sun - Blauvelt NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61P 25/00
A61K 31/551
C07D 243/00
C07D 471/06

US Classification:

514219, 540555

Abstract:

Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.

US Patent:

20100196714, Aug 5, 2010

Filed:

Apr 7, 2010

Appl. No.:

12/755721

Inventors:

Christoph Dehnhardt - New York NY, US
Sreenivasulu Megati - New City NY, US
Jerry Sun - Blauvelt NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 471/04

US Classification:

428402, 540556

Abstract:

Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.

US Patent:

59691638, Oct 19, 1999

Filed:

Oct 9, 1997

Appl. No.:

8/948374

Inventors:

Benjamin J. Frydman - Madison WI
Donald T. Witiak - late of Madison WI
Jerry Shunneng Sun - Madison WI
Andrew H. Geiser - Madison WI

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

C07D31192
C07D30791

US Classification:

549389

Abstract:

A process for the preparation of. beta. -lapachone and dunnione derivatives of formulae I and II ##STR1## wherein, the a solution of lawsone in dimethylsufoxide at a temperature of -78. degree. C. or less is reacted with lithium hydride forming the lithium salt of lawsone; alkylating the lithium salt with an allyl halide; and cyclizing the C-alkylated lawsone derivative.

US Patent:

58247009, Oct 20, 1998

Filed:

Feb 20, 1996

Appl. No.:

8/604131

Inventors:

Benjamin J. Frydman - Madison WI
Donald T. Witiak - Madison WI
Jerry Shunneng Sun - Madison WI
Andrew H. Geiser - Madison WI

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 3135
C07D31192

US Classification:

514454

Abstract:

The invention relates to. beta. -lapachone derivatives of formula II and compositions containing said compounds: ##STR1## wherein, R. sup. 5, R. sup. 6 and R. sup. 7 are as defined in the specification. The compounds are potent inhibitors of neoplastic cell growth and proliferation.