Jian Wang

US Patent:

8492349, Jul 23, 2013

Filed:

Feb 29, 2012

Appl. No.:

13/408734

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - San Diego CA, US

Assignee:

Pain Therapeutics, Inc. - Austin TX

International Classification:

A61K 38/08

US Classification:

514 218

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]—Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

8637435, Jan 28, 2014

Filed:

Nov 14, 2008

Appl. No.:

12/291889

Inventors:

Kevin Caili Wang - Lansdale PA, US
Peter Peizhi Luo - Lansdale PA, US
Pingyu Zhong - Blue Bell PA, US
Jian Wang - Lansdale PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C40B 40/02
C40B 50/06

US Classification:

506 26, 506 14

Abstract:

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.

US Patent:

20090191579, Jul 30, 2009

Filed:

Oct 31, 2008

Appl. No.:

12/263257

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - Groton CT, US

International Classification:

C12Q 1/48
C07K 14/00
C07K 7/08
C07K 7/06
C07K 16/00
G01N 33/566
C12Q 1/02

US Classification:

435 15, 530330, 530324, 530326, 5303879, 436501, 435 29

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]-Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

20120118437, May 17, 2012

Filed:

Oct 31, 2011

Appl. No.:

13/317819

Inventors:

Jian Wang - Murrysville PA, US

International Classification:

B05D 3/00
C21D 6/00

US Classification:

148512, 427321

Abstract:

The present invention is of zinc or zinc alloy coated steel for hot forming having an inorganic overlay covering the zinc or zinc alloy coating to prevent loss of zinc during heating and hot forming. In one embodiment, the inorganic overlay has a coefficient of thermal expansion greater than the coefficient of thermal expansion of zinc oxide. In another embodiment, the inorganic overlay has a compositional gradient interface with the zinc or zinc alloy coating. Preferably the inorganic overlay may be comprised of material selected from phosphates, oxides, nitrates, carbonates, silicate, chromate, molybdate, tungstate, vanadate, titanate, borate, fluoride and mixtures thereof. A method of preparing the steel for hot forming and a method for hot forming the steel are provided.

US Patent:

20120329679, Dec 27, 2012

Filed:

Mar 23, 2012

Appl. No.:

13/428680

Inventors:

Kevin Caili Wang - Lansdale PA, US
Peter Peizhi Luo - Lansdale PA, US
Pingyu Zhong - Blue Bell PA, US
Jian Wang - Lansdale PA, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

C40B 50/06
C12N 15/63
C12N 1/19
C12N 5/10

US Classification:

506 26, 435325, 4353201, 4352542

Abstract:

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.

US Patent:

20140061625, Mar 6, 2014

Filed:

Sep 5, 2013

Appl. No.:

14/019250

Inventors:

Jian Wang - Oakmont PA, US
Sergey Li - Glenshaw PA, US

International Classification:

H01L 51/56
H01L 51/52
H01L 51/50

US Classification:

257 40, 438 46

Abstract:

A device, such as an electroluminescent device, comprising (i) a transparent conductor; (ii) a metal grid disposed on said transparent conductor; and (iii) said metal grid is not covered by an insulator, but by a hole injection layer comprising at least one conjugated polymer and at least one matrix polymer. Methods for making the electroluminescent device are also disclosed.

US Patent:

20220207761, Jun 30, 2022

Filed:

Sep 25, 2019

Appl. No.:

17/601780

Inventors:

- Pittsburgh PA, US
Joseph BARTELS - Pittsburgh PA, US
William L. WHITTAKER - Pittsburgh PA, US
Jian WANG - Pittsburgh PA, US

International Classification:

G06T 7/521
G01B 11/25
G01S 17/48
G01S 17/89

Abstract:

A method to dynamically and adaptively sample the depths of a scene using the principle of triangulation light curtains is described. The approach directly detects the presence or absence of obstacles (or scene points) at specified 3D lines in a scene by sampling the scene. The scene can be sampled sparsely, non-uniformly, or densely at specified regions. The depth sampling can be varied in real-time, enabling quick object discovery or detailed exploration of areas of interest. Once an object is discovered in the scene, adaptive light curtains comprising dense sampling of a region of the scene containing the object, can be used to better define the position, shape and size of the discovered object.

US Patent:

20230041768, Feb 9, 2023

Filed:

Aug 16, 2022

Appl. No.:

17/888670

Inventors:

- Addison TX, US
Jian Wang - Pittsburgh PA, US
Lili Zhang - Beijing, CN

International Classification:

H04L 5/14
H04L 1/00
H04W 52/04
H04W 52/36

Abstract:

A method for operating a communications controller adapted for full duplex (FD) operation includes receiving a measurement report from a user equipment served by the communications controller, the measurement report indicating a first power margin between a current transmit power and a transmit power break point and a second power margin between the current transmit power and a maximum transmit power capable of supporting FD operation, performing FD link adaptation (LA) in accordance with the first power margin and the second power margin to adjust one or more FD configuration parameters of a link between the communications controller and the user equipment, wherein the link includes a downlink and an uplink, and instructing the user equipment to communicate over the link in accordance with the one or more FD configuration parameters.