Joel O Harris

US Patent:

8222259, Jul 17, 2012

Filed:

Mar 3, 2009

Appl. No.:

12/920924

Inventors:

Joel M. Harris - Kenilworth NJ, US
Bernard R. Neustadt - Kenilworth NJ, US
Jinsong Hao - Kenilworth NJ, US
Andrew W. Stamford - Kenilworth NJ, US

Assignee:

Schering Corporation - Rahway NJ

International Classification:

C07D 487/12
C07D 487/14
C07D 487/04
A61K 31/519

US Classification:

514257, 5142621, 514267, 544256, 544251, 544247

Abstract:

Compounds of the Formula I wherein Rand Rtogether with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.

US Patent:

8415353, Apr 9, 2013

Filed:

Mar 3, 2009

Appl. No.:

12/920928

Inventors:

Joel M. Harris - Kenilworth NJ, US
Bernard R. Neustadt - Kenilworth NJ, US
Hong Liu - Kenilworth NJ, US
Jinsong Hao - Kenilworth NJ, US
Andrew W. Stamford - Kenilworth NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/495

US Classification:

514249, 544353, 548131, 548143, 548159, 548202, 5483647, 549434

Abstract:

Compounds of the Formula (I), where W represents CH or N; and Q represents —CN, —C(═NOH)NH, —CONHRor various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine Areceptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.

US Patent:

20080070892, Mar 20, 2008

Filed:

Sep 13, 2007

Appl. No.:

11/854623

Inventors:

Joel Harris - Summit NJ, US
Bernard Neustadt - West Orange NJ, US
Stephen Sorota - Glen Rock NJ, US
Andrew Stamford - Chatham Township NJ, US
Deen Tulshian - Lebanon NJ, US
Brian McKittrick - New Vernon NJ, US

International Classification:

A61K 31/439
A61P 3/06

US Classification:

514210160

Abstract:

Disclosed is a method of treating a disease or condition (e.g., pain, diabetes or disorders of lipid metabolism) comprising administering an azetidine derivative of the formula I selected from the group consisting of the compounds defined by Tables 1, 2, 3a, 3b, 3c, 3d and 4a.

US Patent:

20110065671, Mar 17, 2011

Filed:

May 18, 2009

Appl. No.:

12/993363

Inventors:

Joel M. Harris - Summit NJ, US
Santhosh Francis - Edison NJ, US
Bernard R. Neustadt - West Orange NJ, US
Craig D. Boyle - Branchburg NJ, US
Hong Liu - Hillsborough NJ, US
Jinsong Hao - Belle Mead NJ, US
Samuel Chackalamannil - Califon NJ, US
William J. Greenlee - Teaneck NJ, US

International Classification:

A61K 31/675
C07D 239/90
A61K 31/517
C07D 401/12
A61K 31/496
C07F 9/40
C07D 471/04
A61K 31/519
C07D 413/10
A61K 31/5377
A61P 3/00
A61P 9/00

US Classification:

514 80, 544287, 5142663, 544284, 51425217, 544244, 544279, 5142641, 544116, 5142345

Abstract:

The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bi-cyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient.

US Patent:

20110118286, May 19, 2011

Filed:

Jul 15, 2009

Appl. No.:

13/054347

Inventors:

Santhosh Francis Neelamkavil - Scotch Plains NJ, US
Craig D. Boyle - Branchburg NJ, US
Joel M. Harris - Summit NJ, US
Andre Stamford - Chatham Township NJ, US
Jinsong Hao - Belle Meade NJ, US
Bernard R. Neustadt - West Orange NJ, US
Samuel Chackalamannil - Califon NJ, US
Yan Xia - Edison NJ, US
Wiliam J. Greenlee - Teaneck NJ, US

International Classification:

A61K 31/519
C07D 487/04
A61P 3/00

US Classification:

5142611, 544254, 544262, 5142621, 544280, 5142651

Abstract:

The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient.

US Patent:

20120040975, Feb 16, 2012

Filed:

Apr 1, 2010

Appl. No.:

13/260950

Inventors:

Santhosh Francis Neelamkavil - Edison NJ, US
Bernard R. Neustadt - West Orange NJ, US
Andrew Stamford - Chatham Township NJ, US
Yan Xia - Edison NJ, US
Joel M. Harris - Blaine MN, US
Craig D. Boyle - Branchburg NJ, US
Samuel Chackalamannil - Califon NJ, US
Dipshikha Biswas - Woodbridge NJ, US
Hong Liu - Hillsborough NJ, US
Jinsong Hao - Belle Mead NJ, US
Claire M. Lankin - High Bridge NJ, US
Unmesh Shah - Green Brook NJ, US

International Classification:

A61K 31/537
C07D 401/12
C07D 491/08
A61P 3/00
A61K 31/506
C07D 487/08
A61P 3/10
A61P 3/04
C07D 451/06
C07D 498/08

US Classification:

5142305, 544319, 544105, 514269, 544230

Abstract:

The present invention relates to Bridged Bicyclic Heterocycle Derivatives, compositions comprising a Bridged Bicyclic Heterocycle Derivative, and methods of using the Bridged Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.

US Patent:

20140057893, Feb 27, 2014

Filed:

Apr 5, 2012

Appl. No.:

14/110332

Inventors:

Scott Edmondson - Clark NJ, US
Zhiqiang Guo - Morganville NJ, US
Harold B. Wood - Westfield NJ, US
Andrew W. Stamford - Chatham Township NJ, US
Michael W. Miller - Scotch Plains NJ, US
Duane E. DeMong - Somerset NJ, US
Gregori J. Morriello - Randolph NJ, US
Rajan Anand - Fanwood NJ, US
Vincent J. Colandrea - North Brunswick NJ, US
Megan Macala - Westfield NJ, US
Milana Maletic - Summit NJ, US
Cheng Zhu - Edison NJ, US
Yuping Zhu - Basking Ridge NJ, US
Wanying Sun - Edison NJ, US
Kake Zhao - Westfield NJ, US
Yong Huang - West Windsor NJ, US
Joel M. Harris - Minnetonka MN, US
Lehua Chang - Ramsey NJ, US
Nam Fung Kar - Brooklyn NY, US
Zhiyong Hu - Livingston NJ, US
Liping Wang - Cranbury NJ, US
Bowei Wang - Westfield NJ, US
Ping Liu - Westfield NJ, US
Jason W. Szewczyk - Collegeville PA, US
William B. Geiss - Athens NY, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 513/04
C07D 413/14
C07D 413/04
C07D 498/04
C07D 405/04
C07D 471/04
C07D 487/04
C07D 401/12
C07D 211/22

US Classification:

51421018, 546210, 514326, 546209, 546194, 514318, 544319, 514269, 544130, 5142355, 546114, 514301, 544279, 5142641, 544350, 514249, 546115, 514302, 546122, 514300

Abstract:

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

US Patent:

40273130, May 31, 1977

Filed:

Jun 18, 1975

Appl. No.:

5/587856

Inventors:

Herbert Klepper - Brooklyn NY
Walter Hansen - Cold Spring Harbor NY
Joel S. Harris - Valley Stream NY
Farrokh Golesorkhi - Commack NY

Assignee:

Eltra Corporation - New York NY

International Classification:

B41L 1308

US Classification:

415 R

Abstract:

A photocomposing machine and font strip therefor are described which allow type designers to have the flexibility to design typographical characters which are kerned. The photocomposing machine is able to automatically kern those characters which are designed to be kerned. The automatic kerning is accomplished by intentionally offsetting each character's placement on the font strip to the left with respect to the machine's aperture, and providing an optical system in the photocomposing machine which intentionally offsets the projection of the font strip through the aperture of the machine to the right, thereby cancelling the offset of unkerned characters. Kerned characters are placed to the right on the font strip in order to allow the machine's optical system offset to overlap the image of kerned characters on the space normally reserved for the next character.