John Stephen Flanagan

US Patent:

6399326, Jun 4, 2002

Filed:

Jun 27, 1997

Appl. No.:

08/884569

Inventors:

Ming-Ko Chiang - Boston MA
John G. Flanagan - Newton MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12P 2106

US Classification:

435 691, 536 235, 435325, 435471, 4352523, 4353201

Abstract:

We describe here a new class of protein tyrosine phosphatases (PTP), called âPTP-NPâ (for neural and pancreatic) receptors. The sequence of an exemplary PTP-NP gene (SEQ ID No. 1) indicates it encodes a receptor type PTP (SEQ ID No. 2) with a single tyrosine phosphatase domain. Comparison of PTP-NP with the other known PTPs reveals a cysteine-conserved motif in the extracellular domain and, together with their homology in the phosphatase domain, this defines a new subclass of receptor type PTPs.

US Patent:

6728803, Apr 27, 2004

Filed:

Feb 11, 2000

Appl. No.:

09/502947

Inventors:

Jeffrey J. Nelson - Louisville CO
Gary R. Flauaus - Niwot CO
Daniel F. Casper - Poughkeepsie NY
Joseph C. Elliott - North Creek NY
Catherine C. Huang - Poughkeepsie NY
John R. Flanagan - Poughkeepsie NY
Louis W. Ricci - Hyde Park NY

Assignee:

McData Corporation - Broomfield CO

International Classification:

G06F 506

US Classification:

710 60, 710 36, 370398, 370466

Abstract:

A data communication architecture including a plurality of devices having input/output (I/O) ports supporting communication at a first rate and a data processor having a number of I/O ports where each I/O port supports data communication at a second data rate. The second data rate is at least double the first data rate. A communication link coupled to one of the data processor I/O ports supports the second data rate. A bridge device is coupled to the communication link and to the I/O ports of the plurality of devices. The bridge device translates the communication link at the second data rate to a plurality of communication links at the first data rate, where the plurality of communication links at the first data rate are substantially independent of each other.

US Patent:

6777536, Aug 17, 2004

Filed:

Feb 27, 1995

Appl. No.:

08/393462

Inventors:

John G. Flanagan - Newton MA
Hwai-Jong Cheng - Boston MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 1400

US Classification:

530350, 536 231, 536 235, 435 71, 435 691, 4352523, 4353201

Abstract:

The present invention relates to the discovery of a novel EPH receptor ligand, referred to hereinafter as âElf-1â, which protein has apparently broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in vertebrates, and can be used to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

US Patent:

6919313, Jul 19, 2005

Filed:

Apr 1, 2002

Appl. No.:

10/113794

Inventors:

John G. Flanagan - Newton MA, US
Qiang Lu - Brookline MA, US
Edna E. Sun - Brookline MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA

International Classification:

A61K038/17
C07K014/46

US Classification:

514 12, 530350, 514 2, 514 8

Abstract:

Transmembrane B ephrins and their Eph receptors signal hi-directionally. The presently claimed invention describes a cytoplasmic protein, designated PDZ-RGS3, which binds B ephrins through a PDZ domain, and has a regulator of heterotrimeric G protein signaling (RGS) domain. PDZ-RGS3 mediates signaling from the ephrin-B cytoplasmic tail. SDF-1, a chemokine with a G protein coupled receptor, or BDNF, act as chemoattractants for cerebellar granule cells, with SDF-1 action being selectively inhibited by soluble EphB receptor. The claimed invention reveals a pathway that links reverse signaling to cellular guidance, uncovers a novel mode of control for G proteins, and demonstrates a mechanism for selective regulation of responsiveness to neuronal guidance cues. Further, compositions and methods of use are provided for modulating cell migration as a function of chemokines and GPCR interaction, to aid in the treatment of disease states and medical conditions, including cancer and immune responses such as allergy and autoimmune responses. In one embodiment, a method of altering the sensitivity of a cell to a chemokine is provided using a PDZ-RGS3 protein.

US Patent:

6975623, Dec 13, 2005

Filed:

Mar 10, 2004

Appl. No.:

10/798818

Inventors:

Jeffrey J. Nelson - Louisville CO, US
Gary R. Flauaus - Broomfield CO, US
Daniel F. Casper - Poughkeepsie NY, US
Joseph C. Elliott - North Creek NY, US
Catherine C. Huang - Poughkeepsie NY, US
John R. Flanagan - Poughkeepsie NY, US
Louis W. Ricci - Hyde Park NY, US

Assignee:

McDATA Corporation - Broomfield CO

International Classification:

H04L012/66

US Classification:

370352, 370401

Abstract:

A data communication architecture including a plurality of devices having input/output (I/O) ports supporting communication at a first rate and a data processor having a number of I/O ports where each I/O port supports data communication at a second data rate. The second data rate is at least double the first data rate. A communication link coupled to one of the data processor I/O ports supports the second data rate. A bridge device is coupled to the communication link and to the I/O ports of the plurality of devices. The bridge device translates the communication link at the second data rate to a plurality of communication links at the first data rate, where the plurality of communication links at the first data rate are substantially independent of each other.

US Patent:

20020156239, Oct 24, 2002

Filed:

Jul 31, 2001

Appl. No.:

09/921984

Inventors:

John Flanagan - Newton MA, US
Hwai-Jong Cheng - Boston MA, US

International Classification:

C07K014/705
C07K016/28
C07H021/04
C12P021/02
C12N005/06
C12P021/06

US Classification:

530/350000, 530/388220, 536/023500, 435/069100, 435/325000, 435/320100

Abstract:

The present invention relates to the discovery of a novel EPH receptor ligand, referred to hereinafter as “Elf-1”, which protein has apparently broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in vertebrates, and can be used to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

US Patent:

20120231014, Sep 13, 2012

Filed:

Aug 18, 2010

Appl. No.:

13/391210

Inventors:

John G. Flanagan - Weston MA, US
Alan Peter Tenney - New York NY, US
Yingjie Shen - Brighton MA, US
Jerry Silver - Bay Village OH, US

Assignee:

CASE WESTERN RESERVE UNIVERSITY - Cleveland OH
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

A61K 39/395
A61P 25/00
A61K 38/46
A61K 38/17
C12N 5/0793
C12N 5/071

US Classification:

4241581, 435375, 424 946, 514 177, 4241721

Abstract:

A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG) to a cellular (e.g., trans-membrane) PTPσ protein. The neural cell is associated with an injury or neurodegenerative condition.

US Patent:

20130046905, Feb 21, 2013

Filed:

Oct 22, 2012

Appl. No.:

13/657036

Inventors:

International Business Machines Corporation - Armonk NY, US
Daniel F. Casper - Poughkeepsie NY, US
John R. Flanagan - Poughkeepsie NY, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G06F 3/00

US Classification:

710 4

Abstract:

A method of performing an input/output (I/O) processing operation includes obtaining information relating to an I/O operation at a channel subsystem in the host computer system, the channel subsystem including at least one channel having a channel processor and a local channel memory, generating addressing information and forwarding the addressing information to a network interface between the channel subsystem and at least one I/O device, the addressing information specifying a location in the local channel memory. The method also includes forwarding an I/O command message to the at least one I/O device via the network interface, receiving a data transfer request from the network interface that includes the addressing information, accessing one of a plurality of address control words (ACWs), each ACW specifying an address of a location in a host computer memory, and routing the data transfer request to the host memory location specified in the ACW.