John W Harmon

US Patent:

20060148737, Jul 6, 2006

Filed:

Dec 29, 2003

Appl. No.:

10/540934

Inventors:

John Harmon - Baltimore MD, US

Assignee:

The John Hopkins University - Baltimore MD

International Classification:

A61K 48/00
A61N 1/00

US Classification:

514044000, 607002000

Abstract:

Electroporation is used to enhance the wound-healing benefit provided by transfection of nucleic acids that encode cellular growth factors. Wounds which are amenable to the method include inter alia cutaneous lesions, muscular lesions, osseus lesions, burn wounds, and gastrointestinal anastamoses. Kits comprise electrodes and nucleic acids encoding cellular growth factors.

US Patent:

20090030364, Jan 29, 2009

Filed:

Feb 6, 2006

Appl. No.:

11/883554

Inventors:

John W. Harmon - Baltimore MD, US
Guy Pierre Marti - Cockeysville MD, US
Mark John Ferguson - Inverurie, GB

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61N 1/30

US Classification:

604 21, 604 20

Abstract:

A cartridge for administration of a bioactive agent may include a plurality of chambers, including at least a first chamber and a second chamber. Each of the chambers may contain a component of a composition to be administered to a tissue site of a subject. For example, the first chamber may contain the bioactive agent and the second chamber may contain a liquid for suspending the bioactive agent prior to administration to the tissue site. An apparatus for administering or delivering a bioactive agent may include the cartridge and may further include an energy source for providing an electrical pulse to the tissue site. The apparatus may further cause mixing of the bioactive agent with the liquid in the cartridge. For example, the apparatus may impact the cartridge to result in mixing of the bioactive agent with the liquid. A method for combining a bioactive agent with a liquid forms a composition for delivering to a tissue site.

US Patent:

20090186805, Jul 23, 2009

Filed:

Jan 2, 2009

Appl. No.:

12/348164

Inventors:

Aaron Thomas Tabor - Winston-Salem NC, US
John Watson Harmon - Baltimore MD, US

International Classification:

A61K 38/02
C12N 5/06
C12N 15/87
C12N 15/88
A61K 31/7088

US Classification:

514 2, 435375, 435455, 435458, 435461, 435459, 514 44

Abstract:

Disclosed are methods and compositions to genetically modify substantially intact cells having cosmetic function to enhance the cosmetic appearance in mammals so as to enhance and/or maintain a biochemical and/or physiological process that has a positive effect on cosmetic appearance. The methods and compositions may provide cosmetic benefits such as reduced skin sagging, increased skin thickness, reduced wrinkles, increased skin thickness and collagen content, increased skin tone and elasticity, increased skin hydration, and improved skin texture and color.

US Patent:

20090311226, Dec 17, 2009

Filed:

May 22, 2007

Appl. No.:

12/300685

Inventors:

John W. Harmon - Baltimore MD, US
Guy Pierre Marti - Cockeysville MD, US
Tomoharu Miyashita - Baltimore MD, US
Michael Gibson - Baltimore MD, US
Todd Armstrong - Elkridge MD, US
Pramod Bonde - Abingdon MD, US

Assignee:

THE JOHN HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 48/00
A61P 35/00
A61K 35/00
A61K 35/12

US Classification:

424 9321

Abstract:

Enhancing the immune response to esophageal tumor cells reduces the incidence of esophageal cancer developing, recurring, or metastasizing. Esophageal cancer cells are modified to render them more immunogenic and proliferation compromised. They are used in an antigenic preparation to raise a T cell response in the recipient.

US Patent:

20120115938, May 10, 2012

Filed:

Jul 15, 2010

Appl. No.:

13/383612

Inventors:

Aaron T Tabor - Winston-salem NC, US
John Harmon - Baltimore MD, US

International Classification:

A61K 48/00
A61P 17/00
A61M 37/00
C12N 15/63

US Classification:

514 44 R, 435455, 604 22, 604 20

Abstract:

Disclosed are methods and compositions to genetically modify substantially intact cells having cosmetic function to enhance the cosmetic appearance in mammals so as to enhance and/or maintain a biochemical and/or physiological process that has a positive effect on cosmetic appearance. The methods and compositions may provide cosmetic benefits such as reduced skin sagging, increased skin thickness, reduced wrinkles, increased skin thickness and collagen content, increased skin tone and elastic-ity, increased skin hydration, and improved skin texture and color.

US Patent:

D2666111, Oct 19, 1982

Filed:

May 21, 1981

Appl. No.:

6/265973

Inventors:

Thomas Metts - Stafford VA
John R. Harmon - Stafford VA

International Classification:

D3003

US Classification:

D30 15

US Patent:

20190175641, Jun 13, 2019

Filed:

Dec 3, 2018

Appl. No.:

16/208318

Inventors:

- Baltimore MD, US
Xianjie Zhang - Baltimore MD, US
John W. Harmon - Baltimore MD, US
Guoming Sun - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/738
A61K 9/00
A61K 9/06
A61K 38/18
A61L 27/20
A61L 27/52
A61L 27/54

Abstract:

Methods for promoting skin regeneration, promoting hair follicle regeneration, and reducing scarring by topically administering polysaccharide-based hydrogel compositions to injured skin are presented.

US Patent:

20150174154, Jun 25, 2015

Filed:

Apr 24, 2012

Appl. No.:

14/115237

Inventors:

Sharon Gerecht - Baltimore MD, US
Xianjie Zhang - Baltimore MD, US
John W. Harmon - Baltimore MD, US
Guoming Sun - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 31/738
A61K 38/18

Abstract:

Methods for promoting skin regeneration, promoting hair follicle regeneration, and reducing scarring by topically administering polysaccharide-based hydrogel compositions to injured skin are presented.