Jonathan Lynn Martin

US Patent:

6490913, Dec 10, 2002

Filed:

May 18, 2000

Appl. No.:

09/573277

Inventors:

Jonathan W. Martin - Montgomery Village MD
Edward Embree - Frederick MD
Mark R. VanLandingham - Gaithersburg MD

Assignee:

The United States of America as represented by the Secretary of Commerce - Washington DC

International Classification:

G01B 1130

US Classification:

73105, 738656

Abstract:

The present invention provides a novel humidity chamber suitable for use with an atomic force microscope (AFM). The humidity chamber of the present invention employs an intricate geometrical design which can accommodate a scanned-stylus AFM with an optical lever. This geometrical design allows the invention to enclose one or more of the AFM scanner, tip assembly, optical lever detection system, sample and an optical microscope objective lens, without degrading the ability to operate the AFM or the related systems. The invention is comprised of two major pieces: a chamber within which the AFM scanning head assembly is placed, and an integrated sample platform and spring-loaded base-plate that allows samples to be loaded and unloaded without removal of the chamber from the AFM scanning head assembly. The sample platform, which extends up from the base-plate and is inserted into the chamber, can include a magnet that is securely attached to the base. Once the sample platform is positioned inside the chamber, a locking pin can be inserted between the chamber and the bottom portion of the sample platform to secure the sample platform and base-plate.

US Patent:

6626052, Sep 30, 2003

Filed:

Aug 2, 1999

Appl. No.:

09/180079

Inventors:

Jonathan Martin - Gaithersburg MD
Joannie Chin - Frederick MD

Assignee:

The United States of America as represented by the Secretary of the Commerce - Washington DC

International Classification:

G01N 1700

US Classification:

738656, 356236, 250228

Abstract:

A method and apparatus for irradiating a specimen with a beam of radiation are provided. The method comprises the steps of providing an integrating sphere, a radiation source radiatively communicating with the sphere, and a specimen, the integrating sphere radiatively communicating with the specimen through an aperture in the sphere. The apparatus comprises a radiation source, an integrating sphere in radiative communication with the radiation source, and a specimen holder in radiative communication with the integrating sphere. The disclosed apparatus and method allow the irradiance of a beam of radiation impinging on the specimen to be maintained at a uniform level across the width of the beam to allow quantitative specimen evaluation.

US Patent:

55591442, Sep 24, 1996

Filed:

May 5, 1995

Appl. No.:

8/435399

Inventors:

Dee W. Brooks - Libertyville IL
Andrew O. Stewart - Wildwood IL
Daniel J. Kerkman - Lake Villa IL
Pramila A. Bhatia - Mundelein IL
Anwer Basha - Lake Forest IL
Jonathan G. Martin - Knoxville TN

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3134
A61K 3138
C07D30746
C07D33322

US Classification:

514445

Abstract:

Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or --NR. sup. 1 R. sup. 2, where R. sup. 1 and R. sup. 2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

54768730, Dec 19, 1995

Filed:

Apr 19, 1994

Appl. No.:

8/229860

Inventors:

Dee W. Brooks - Libertyville IL
Andrew O. Stewart - Wildwood IL
Daniel J. Kerkman - Lake Villa IL
Pramila A. Bhatia - Mundelein IL
Anwer Basha - Lake Forest IL
Jonathan G. Martin - Knoxville TN

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C25906
C07C27318
C07C27564
A61K 3117

US Classification:

514595

Abstract:

Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or --NR. sup. 1 R. sup. 2, where R. sup. 1 and R. sup. 2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

51838184, Feb 2, 1993

Filed:

Aug 27, 1991

Appl. No.:

7/750362

Inventors:

Dee W. Brooks - Libertyville IL
Andrew O. Stewart - Wildwood IL
Jonathan G. Martin - Knoxville TN

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3138
C07D33332

US Classification:

5142315

Abstract:

The present invention provides compounds having the structure Y-Het-[Q. sub. 1 ]-X-[Q. sub. 2 ]-Z which inhibit the catalytic action of lipoxygenase enzymes, particularly 5-lipoxygenase, and thereby reduce the biosynthesis of leukotrienes B. sub. 4, C. sub. 4, D. sub. 4, and E. sub. 4. In the generic formula given above, X is oxygen or sulfur and Het is a heteroaryl group selected from the group consisting of furyl, thienyl, 2-, 3-, and 4-pyridyl, 2- and 3-benzo[b]furyl, 2- and 3-benzo[b]thienyl and thienothienyl. Y is one or two substituents independently selected from hydrogen, hydroxy, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkoxyaryl), alkylthioaryl, arylalkoxy, arylalkylthio, aryloxy, arylthio, alkylamido, cycloalkyl, alkanoyl, alkoxycarbonyl, amino, alkylamino, dialkylamino, and the following groups wherein R, at each occurrence, is independently selected from hydrogen and alkyl of from one to six carbon atoms: --CRROR, --NRC(O)R, --NRC(O)OR, and --C(O)NRR. The group Q. sub. 1 is absent or is divalent alkylene of from one to six carbon atoms, and Q. sub.

Address:

2929 Connecticut Ave NW, Washington, DC 20008

VIN:

3VWRF71K57M044949

Make:

VOLKSWAGEN

Model:

VOLKSWAGEN

Year:

2007