Joshua R Gilmore

US Patent:

20120135524, May 31, 2012

Filed:

Apr 15, 2011

Appl. No.:

13/088288

Inventors:

Joshua M. Gilmore - Emeryville CA, US
J. Christopher Anderson - San Francisco CA, US
John E. Dueber - San Francisco CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12N 15/01
C12N 15/70
C12N 1/21
C12N 15/11

US Classification:

435441, 536 231, 4353201, 43525233

Abstract:

The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each construct can, independently, further comprise one or more genes encoding a recombinase capable of recognizing the pair of recombinase recognition sequences of the construct. The recombinase can be an orthogonal (non-cross reacting), site-selective recombinase (OSSR).