- Stanford CA, US Doris Po Yi Ho - Daly City CA, US Kelly Marie McKenna - Palo Alto CA, US Irving L. Weissman - Stanford CA, US Jens-Peter Volkmer - Menlo Park CA, US Mark P. Chao - Mountain View CA, US Ravindra Majeti - Palo Alto CA, US Melissa N. McCracken - Mountain View CA, US
International Classification:
C07K 16/28 A61K 45/06 A61K 39/395
Abstract:
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of immunoregulatory agents. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.
Treatment Of Cancer With Dual Targeting Of Cd47 And Egfr
- Stanford CA, US Stephen Willingham - Sunnyvale CA, US Doris Po Yi Ho - Stanford CA, US Piero D. Dalerba - New York NY, US Kelly Marie McKenna - Palo Alto CA, US Jens-Peter Volkmer - Menlo Park CA, US
International Classification:
C07K 16/28
Abstract:
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.
University of Washington - School of Medicine
Medical Doctor and Phd Student
Stanford University School of Medicine May 2012 - Aug 2016
Life Science Research Assistant
Forty Seven, Inc. May 2012 - Aug 2016
Research Associate, Level Ii
Christian Music Theater Jun 2005 - Jun 2012
Head Counselor
Education:
Santa Clara University 2009 - 2013
Bachelors, Bachelor of Science, Biology
Gunn High School
University of Washington - School of Medicine
Doctor of Medicine, Doctorates, Doctor of Philosophy
Skills:
Pcr Research Powerpoint Data Analysis Public Speaking Agarose Gel Electrophoresis Microsoft Word Microsoft Excel Microsoft Office Public Health Molecular Biology Teamwork Spss Statistics